A single base change makes a difference
There's a new paper in Science that investigates the effect of a single SNP (single nucleotide polymorphism) on memory usage effectiveness. People with the Thymine base in a certain locus do markedly better in task involving short-term memory than those with the Cystine base at that location. The location affects the protein KIBRA.
See this discussion by John Hawks, which has links to the original paper and some other references.
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