Hormone causing reabsorption of glucose

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Discussion Overview

The discussion revolves around identifying the hormone responsible for the reabsorption of glucose in the nephrons, particularly in the context of renal physiology. Participants explore the mechanisms of glucose reabsorption and the potential hormonal influences involved.

Discussion Character

  • Debate/contested
  • Technical explanation
  • Conceptual clarification

Main Points Raised

  • One participant inquires about the hormone responsible for glucose reabsorption in the nephrons.
  • Another participant asserts that glucose reabsorption occurs in the proximal tubule, suggesting that someone must know the hormone involved.
  • Some participants mention Antidiuretic Hormone (ADH) and Aldosterone but express uncertainty about their roles in glucose reabsorption.
  • It is noted that ADH primarily affects water reabsorption and Aldosterone influences sodium reabsorption, with no direct impact on glucose reabsorption.
  • One participant claims that 100% of glucose is absorbed in the proximal tubule without significant hormonal influence, describing the process as facilitated transport using a sodium-glucose symporter.
  • Another participant agrees that there is no direct hormonal control over glucose reabsorption, emphasizing the role of sodium gradients maintained by Na+-K+ ATPase in the process.
  • A later reply mentions that while sodium levels may be hormonally regulated, glucose reabsorption itself is not directly mediated by hormones.
  • One participant reports that the instructor indicated cortisol as the answer, prompting confusion among others regarding the reasoning behind this claim.

Areas of Agreement / Disagreement

Participants generally agree that there is no direct hormonal control of glucose reabsorption in the proximal tubule, but there is disagreement regarding the role of cortisol, with some expressing skepticism about its involvement.

Contextual Notes

Participants note that the mechanisms of glucose reabsorption involve active transport and co-transport with sodium, but the exact hormonal influences remain unclear and contested.

Coldie
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Can anybody tell me what the hormone that causes the reabsorption of glucose in the nephrons is?

Thanks.
 
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The reabsorption of glucose in the proximal tubule of the nephrons! Come on, SOMEone must know this!
 
I know of two. I don't know which one helps that process.

Antidiuretic Hormone (ADH), produced by the pituitary gland.
Aldosterone, produced by the adrenal cortex.
 
We're familiar with those two. ADH causes the reabsorption of water to increase, and Aldosterone just causes an increase in the reabsorption of Na+ and the excretion of K+. To my understanding, neither of these do anything concerning the reabsorption of glucose. That's why this was such a challenge. I've been unable to find anything on it yet, which is why I made thsi thread.
 
My memory is vague but I believe there is no hormonal effect.

100% of the glucose is absorbed in the proximal tubule of the nephron where very little hormonal effects are felt. That I know.

The glucose is absorbed via a facilitated transport system where the potential energy of the sodium ion is somehow used to go against the glucose concentration gradient. We also called it contransport and its mechanism is not fully known. (At least my vague reccollection of it). I think it appears that the affinity for the "carrier" for glucose in the epithelium is somehow enhanced by the attachment of the Na+ to that carrier. That's all I know, and I'm not sure if it answers your question.
 
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That sounds good, and I'll approach my Bio teacher with that answer, but he did ask us for the hormone that caused it.
 
I have to agree with Adrenaline, that there is no direct hormonal control of the reabsorption of glucose in the proximal tubule. It's driven by an active transport process using a sodium/glucose symporter (as mentioned by Adrenaline) the carries in glucose by the co-transport of sodium down its concentration gradient. This gradient is maintained by a Na+-K+ ATPase which consumes ATP to pump out sodium and bring in potassium. This gradient is used to drive numerous processes throughout the body, especially in neurons. Now it could be argued that the sodium is controlled by hormones such as those listed at the bottom of http://sprojects.mmi.mcgill.ca/nephrology/ions/sodium.asp and thus anything downstream of this is thus controlled by said hormones, but I would have to say that the question as you stated it is probably not directly mediated by a hormone.
 
Last edited by a moderator:
Thanks! I'll e-mail him with that and see what he says about it.
 
Thanks for the bonus mark on the test, guys!:D

The answer he was looking for was cortisol, but your explanations were infallable. Thanks again!
 
  • #10
How was he reasoning cortisol? I know of no evidence for that being a function of cortisol. :confused:
 

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