 Quote by Pythagorean
1) it's not just the outline. The internal structure of the brain is well represented to.
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Not at all. The whole overlay you posted is forced. The actual shapes in the painting have to be blotted out to make the overlay work.
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2) It's not just the shapes he painted, but also that he flayed corpses to study their anatomy.
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He may have seen a human brain, but so what?
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3) All it can ever be is speculation (since forthcoming would have done a lot of harm to Michelangelo) but there's a lot of evidence suggestive of Michelangelo's disdain for the commission.
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It's thoroughly and incontrovertibly documented that he completely hated the job. It wasn't a commission, it was an offer he couldn't refuse. The pope sent armed men to bring him back to Rome. He was completely ticked off at the Pope, not at God. As I demonstrated earlier, he was never secular, ever in his life. He was a kind of fundamentalist/superstitious Catholic, he believed in damnation for sinners, miracles, and the very real wrath of God through floods and other natural disasters. He once left Florence in a hurry when a friend had a series of prophetic visions about the violent overthrow of the ruler of Florence if he didn't atone for his sins. These came true: de Medici was indeed, toppled from power. Michelangelo was, all his life, a true believer.
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Anyway, of course I don't know whether the brain was intentional on Michelangelo's part, but I don't think it's as clear-cut a case of pareidolia as you do.
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If it wasn't intentional, it wasn't a brain, just compositional drapery.