Why do halogen substituents make molecules more lipophilic?

by CrimpJiggler
Tags: halogen, lipophilic, molecules, substituents
CrimpJiggler is offline
Oct27-11, 01:14 PM
P: 149
I was reading about the effects of adding substituents in designing drugs and read that halogens, like methyl groups, make the molecule more lipophilic. Don't halogens would make molecules more polar since they are so electronegative? I thought halogens would make a molecule more hydrophilic and less lipophilic, how is it the other way around?
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