Why is zone 1 in liver more prone to ischemic injury?

[sameeralord]

Hi,

Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why does eclampsia cause zone 1 necrosis. Thanks :)

 

[SW VandeCarr]

Hi,

Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why does eclampsia cause zone 1 necrosis. Thanks :)

Zone 1 is the periportal zone. Although a vein, the portal vein supplies about half the liver's oxygenation in the normal situation, but this is reduced in cirrhosis. The hepatic artery normally supplies the other half. Zone 1 is more prone to toxic and viral injury (hepatitis). Zone 3 is normally the least oxygenated of the hepatic zones and the most prone to ischemic injury.

http://www.ncbi.nlm.nih.gov/pubmed/8455423

http://www.google.com/search?q=hepa...11%2F01%2Fanatomy-hepatic-veins.html;1078;851

EDIT: Look up the roles of the portal circulation and of the hepatic central veins.

 

[mazinse]

Zone 1 is the periportal zone. Although a vein, the portal vein supplies about half the liver's oxygenation in the normal situation, but this is reduced in cirrhosis. The hepatic artery normally supplies the other half. Zone 1 is more prone to toxic and viral injury (hepatitis). Zone 3 is normally the least oxygenated of the hepatic zones and the most prone to ischemic injury.

double check here, the portal vein shouldn't have any oxygen you mean nutrients right from the GI.

to the original question, ecclampsia is a vascular damage, so yeah the logic stands

 

[SW VandeCarr]

double check here, the portal vein shouldn't have any oxygen you mean nutrients right from the GI.

to the original question, ecclampsia is a vascular damage, so yeah the logic stands

Hepatic portal vein blood does not have as high an oxygen content per unit volume as arterial blood, but it does in fact supply half the oxygen demand of the liver in the normal situation. This is reduced with cirrhosis. Because it transports a large volume of blood, the portal system can normally meet its share of the liver's oxygen requirements. Venous blood is not totally deoxygenated. Did you do any research before you posted? Did you read the link in the post you quoted?

http://en.wikipedia.org/wiki/Liver see Blood Flow

 

[LudusRex]

The reason why zone 1 in the liver is more prone to ischemic injury is due to its location and blood supply. Zone 1 is located around the central vein, which receives deoxygenated blood from the hepatic artery and portal vein. This area is more sensitive to ischemia (lack of oxygen) because it is the furthest from the main source of oxygenated blood, the hepatic artery. This makes it more susceptible to damage when there is a decrease in blood flow or oxygen supply, such as in cases of shock or low blood pressure.

Eclampsia, a condition that occurs during pregnancy, can also cause zone 1 necrosis. This is because eclampsia is associated with high blood pressure and decreased blood flow to the liver, particularly in the central vein area. This decreased blood flow can lead to ischemia and damage to the cells in zone 1, resulting in necrosis (cell death).

In summary, the location and blood supply of zone 1 in the liver make it more vulnerable to ischemic injury, which can be caused by various factors such as shock or eclampsia.