Manganese Toxicity: Investigating Molecular & Systems Level Changes

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In summary, the conversation discusses the topic of manganese toxicity and its effects on the nervous system and cognitive function. The speaker is curious about the connection between manganese exposure and symptoms and also inquires about the effects of other transition metals on organisms. However, there is still uncertainty and a need for further understanding in this area.
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Kglocc
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I've done a bit of reading about manganese toxicity recently, and I was just wondering if anyone had anything to contribute about this topic. It seems evident from the research I've read that excess manganese (ingested or inhaled) is linked to problems in the nervous system similar to Parkinsons, as well as mild ADD like symptoms, and general cognitive dysfunction.
How do you go from manganese toxicity to changes at the molecular/systems levels? The association is evident, but there's still some "magical hand waving" going on between exposure and symptoms I would like to understand. I'd also be interested in how toxic levels of iron, calcium or any other transition metals could affect an organism.
 
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I'd like to answer you but I don't know.
 

1. What is manganese toxicity?

Manganese toxicity is a condition in which there is excessive accumulation of manganese in the body, leading to adverse effects on health. It can occur due to occupational exposure, excessive intake of manganese supplements, or environmental contamination.

2. What are the symptoms of manganese toxicity?

The symptoms of manganese toxicity vary depending on the level of exposure and individual susceptibility. Common symptoms include neurological effects such as tremors, difficulty in coordination and balance, and cognitive impairment. Other symptoms may include respiratory problems, skin irritation, and digestive issues.

3. How does manganese toxicity affect the body at a molecular level?

Manganese toxicity has been linked to oxidative stress, inflammation, and changes in gene expression in various tissues. It can also disrupt the balance of essential trace elements in the body, leading to further health complications.

4. What are the systems level changes caused by manganese toxicity?

Manganese toxicity can affect multiple systems in the body, including the nervous, respiratory, and digestive systems. It can also lead to cardiovascular complications and impair the body's ability to detoxify harmful substances.

5. How is manganese toxicity diagnosed and treated?

Diagnosis of manganese toxicity involves measuring the levels of manganese in blood, urine, or hair samples. Treatment mainly focuses on reducing exposure to manganese and managing symptoms. In severe cases, chelation therapy may be used to remove excess manganese from the body.

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