What is the effect of thiazide diuretics on GFR?

  • Thread starter Manish7
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In summary, thiazide diuretics are a type of medication commonly used to treat high blood pressure and conditions such as edema, congestive heart failure, liver cirrhosis, and kidney disease. They work by targeting the kidneys and reducing sodium reabsorption, resulting in increased urine output and lower blood pressure. Common side effects include increased urination, dizziness, and muscle cramps, while more serious side effects and drug interactions may occur. It may take a few days to weeks for thiazide diuretics to start working and it is important to continue taking them as prescribed and monitoring their effectiveness.
  • #1
Manish7
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Having a little query that what is the effect of diuretics (both thiazides and loops)
on GFR ?
Athough katzung 12th edi. says loops _ no effect on gfr, but it is silent on thiazides ?
no thiazides are given when GFR <30ml/min except metolazone while loop diuretics are given in
heart failure with compromised renal functions(failure). why??
 
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  • #2
I'm sorry you are not finding help at the moment. Is there any additional information you can share with us?
 

1. What are thiazide diuretics?

Thiazide diuretics are a type of medication commonly used to treat high blood pressure by increasing the amount of water and salt expelled from the body through urine. They work by targeting the kidneys and reducing the reabsorption of sodium, resulting in increased urine output and lower blood pressure.

2. What conditions are thiazide diuretics used to treat?

Aside from high blood pressure, thiazide diuretics are also used to treat edema (fluid retention) associated with conditions such as congestive heart failure, liver cirrhosis, and kidney disease. They may also be prescribed to prevent calcium kidney stones in patients with high levels of calcium in their urine.

3. What are the potential side effects of thiazide diuretics?

Common side effects of thiazide diuretics include increased urination, dizziness, headache, muscle cramps, and low levels of potassium in the blood. In rare cases, more serious side effects such as allergic reactions, electrolyte imbalances, and kidney problems may occur. It is important to discuss potential side effects with your doctor before starting this medication.

4. Can thiazide diuretics interact with other medications?

Yes, thiazide diuretics can interact with other medications, including blood pressure medications, nonsteroidal anti-inflammatory drugs (NSAIDs), and some antidepressants. It is important to inform your doctor of all medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.

5. How long does it take for thiazide diuretics to work?

The exact timing of when thiazide diuretics start working may vary from person to person. In general, it may take a few days to a few weeks to notice a decrease in blood pressure. However, it is important to continue taking the medication as prescribed and follow up with your doctor to monitor its effectiveness.

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