What is the action of acetylcholine and anticholinesterase. Confused

[sameeralord]

What is the action of acetylcholine and anticholinesterase. Confused!

Hello everyone,

Ok Acetylchlone is released from postganglionic parasympathetic fibres and preganglionic nerve fibres of both sympathetic and parasympathetic nerves. It also cause muscle contraction in neuromuscular junction. So anticholinesterase would increase acetylcholine level---> Now what would be the effects of increased acetylcholine. Ok I understand parasympathetic activity would be increased, but if lots of acetylcholine is there in preganglionic nerve fibres of sympathetic fibres now, shouldn't sympathetic activity also increase. So what is the final effect.Also in anticholinesterase poisoning what are the clinical effects. I can't work it out because of my previous confusion. Is is like pupillary constriction and bronchoconstriction if parasympathetic predominates. Also increased muscle contraction. Also if I use anticholinesterase in combination with a competitive agonist and neuromuscular blocking agent such as tubocurarine would this decrease the action of tubercurine, because now it has compete with acetylcholine.

Thanks for help in advance

 

[mazinse]

first high acetylcholine levels would be at the end organ level, not junction.

The effects of overdose is exactly like you said, plus a couple of other ones you can probably find onlline

 

[sameeralord]

first high acetylcholine levels would be at the end organ level, not junction.

The effects of overdose is exactly like you said, plus a couple of other ones you can probably find onlline

Hey thanks for taking your time to help But could u please elaborate when you say "first high acetylcholine levels would be at the end organ level, not junction." Does this mean that if i give a cholinergic drugs (acetylcholine agonists), they will travel through the blood stream and reach the organs first, so by the time they reach nerve junctions there concentration would be very low hence minimum sympathetic activity.

 

[mazinse]

yeah that's what i am thinking, especially since acetylcholine's half life isn't that long to begin with.

 

[LudusRex]

Hello,

Acetylcholine is a neurotransmitter that plays a crucial role in the transmission of nerve impulses in the nervous system. It is released from nerve cells and binds to specific receptors on target cells, causing various physiological responses. One of its main actions is to stimulate muscle contraction in the neuromuscular junction, which allows for movement and motor function.

Anticholinesterase, on the other hand, is a class of drugs that inhibit the activity of acetylcholinesterase, the enzyme responsible for breaking down acetylcholine. By blocking this enzyme, anticholinesterase increases the level of acetylcholine in the body, leading to prolonged and intensified effects of acetylcholine on target cells.

In terms of its effects on the autonomic nervous system, increased levels of acetylcholine can lead to increased parasympathetic activity, which can cause pupillary constriction, bronchoconstriction, and increased muscle contraction. However, it can also have an impact on sympathetic activity, which can lead to increased heart rate, blood pressure, and pupil dilation.

In cases of anticholinesterase poisoning, the clinical effects can vary depending on the specific drug and dosage. However, some common symptoms may include excessive salivation, sweating, diarrhea, muscle weakness, and difficulty breathing. In severe cases, it can also lead to paralysis and respiratory failure.

As for your question about using anticholinesterase in combination with a competitive agonist and neuromuscular blocking agent, it is possible that the effects of the neuromuscular blocking agent may be reduced due to the increased levels of acetylcholine. However, the exact mechanism and extent of this interaction may vary depending on the specific drugs and their dosages.

I hope this helps to clarify your confusion. If you have any further questions, please don't hesitate to ask. As a scientist, it is important to always seek a deeper understanding of complex concepts. Keep up the curiosity and critical thinking!