Telomere in Neuron Reprogramming

[Anand Wilson]

what will be function of TERT,and shelterin complex protein in Neuron regeneration,is their any variant in telomere and telomerase between normal neuron and reprogramm neurons?

 

[Greg Bernhardt]

I'm sorry you are not generating any responses at the moment. Is there any additional information you can share with us? Any new findings?

 

[Anand Wilson]

Extre telomeric function of TERT

Recently a paper published on april 2014,their is a extra telomeric function role while reprogramming of somatic cell

 

[atyy]

Recently a paper published on april 2014,their is a extra telomeric function role while reprogramming of somatic cell

Could you give the exact reference?

 

[LudusRex]

I can provide some insight into the role of telomeres and telomerase in neuron reprogramming and regeneration.

Telomeres are repetitive DNA sequences found at the ends of chromosomes that protect them from degradation and fusion with other chromosomes. They play a crucial role in maintaining the stability and integrity of the genome. Telomere length is maintained by the enzyme telomerase, which adds telomeric DNA repeats to the ends of chromosomes.

In neuron reprogramming, the process of converting one type of neuron into another, telomeres and telomerase have been found to play a critical role. Studies have shown that during the reprogramming process, there is an increase in telomerase activity, leading to elongation of telomeres. This suggests that telomerase is necessary for the successful reprogramming of neurons.

Additionally, the shelterin complex, a group of proteins that bind to telomeres, has also been found to play a role in neuron regeneration. These proteins help protect the telomeres and maintain their stability. In the context of neuron regeneration, the shelterin complex is thought to help prevent DNA damage and promote cell survival.

There is some evidence that there may be differences in telomere length and telomerase activity between normal neurons and reprogrammed neurons. However, more research is needed to fully understand these differences and their significance.

In conclusion, telomeres and telomerase play important roles in neuron reprogramming and regeneration. The function of TERT and shelterin complex proteins in maintaining telomere length and stability is crucial for the success of these processes. Further studies are needed to fully understand the differences in telomere biology between normal and reprogrammed neurons.