Why is there no fix for Male Pattern Baldness?


by Jamin2112
Tags: baldness, male, pattern
nitsuj
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#19
Oct15-13, 12:18 PM
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Quote Quote by SteamKing View Post
I don't know why the medical community is wasting time and resources on trivial problems like curing cancer or fighting infectious disease or birth defects when they should be confronting some really superficial issues like MPB.

Maybe that's what's lacking: people refer to the condition as 'male pattern baldness' when they should be referring to 'MPB'. That makes it sound like something which could strike anyone, anywhere, anytime. There could be an MPB Campaign, Walk for an MPB Cure, Raising MPB Awareness campaigns, the wearing of the Steel Gray Ribbon to show your Support to Find a Cure for MPB.
ahahaa I share your take on this. The first billboard leaving our international airport is an ad for hair transplants or some other technique. Show a bald dude who's all ashamed looking and the wording on the sign is talking about lacking confidence. really, its more transparent and shallow then the ads girls are bombarded with.

Where is the billboard for my shame for being short and weak, my god now that I think of it...I'm short, balding and weak...oh cruel world! Take my money until Im beautiful like you want me to be teeheehee so glad im not self conscious...I'd have a fair bit to feel bad about with my appearance lol
skeptic2
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#20
Oct15-13, 12:45 PM
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No one has mentioned the only permanent solution - castration.
Ryan_m_b
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#21
Oct15-13, 12:56 PM
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IIRC castration only works if done before balding, it doesn't restore hair.
mishrashubham
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#22
Oct16-13, 08:23 AM
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Frankly I don't care too much. Just comb it in a way that it isn't too noticeable may be. I'm planning to shave my head in a few years anyways.

Quote Quote by Ryan_m_b View Post
IIRC castration only works if done before balding, it doesn't restore hair.
I'd take that as a joke XD
Ryan_m_b
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#23
Oct16-13, 08:28 AM
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Actually it wasn't
http://jcem.endojournals.org/content/20/10/1309.short

You can find many other papers using the search term "castration and baldness". Like you though I think I'll just learn to live with it when the time comes.
guy3288
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#24
Oct16-13, 10:16 AM
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still no one is convinced with finasteride? Dont wait till it is too late, that is about the only medically proven therapy.
Jamin2112
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#25
Oct16-13, 11:01 AM
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Quote Quote by guy3288 View Post
still no one is convinced with finasteride? Dont wait till it is too late, that is about the only medically proven therapy.
I haven't seen any solid evidence that "fin" is effective.

I know that a lot of people who take it claim it has slowed their hair loss. 2 thoughts on that:

(1) Why would you want to slow down the inevitable? That just makes you stay for a longer time in the stage where you're trying to hide your loss and where you're stressed out by the uncertainty of not knowing how bad your hair loss will eventually be. I would rather take a pill that speeds up my hair loss to its final resting state.

(2) The people who claim to have experienced a decrease in hair loss after taking fin could be experiencing the placebo effect or a coincidence. Lots of people lose some hair and then don't lose any more; that's their "mature hairline" taking form. My guess would be that a lot of guys who take fin in their 20's were not headed towards the full cue ball to begin with, but they assumed the worst and now they think that fin saved them.

Not to mention the fact that the chemical compound causing hair loss (DHT) has been shown to be important for cognitive functioning. It's probably not good to be taking a DHT-blocking drug.

Personally, I'm not going to take any drugs. I'm just going to hope for the best and put my faith in science. I have only minor recession so far. Maybe I won't have any more. At the very least, I'm sure that a couple years from now hair transplant surgery will have been perfect and much cheaper, just like what happened with laser eye surgery. That's the worst-case scenario, though. If stem cell research takes off, we could have a much better solution.
Evo
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#26
Oct16-13, 11:04 AM
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Caffeine. Seriously.

It seems DHT causes male pattern Baldness and caffeine reverses the effects (to some degree), I assume if it was significant it would be major news.

Male pattern baldness, also known as androgenic alopecia or androgenetic alopecia, is caused by the hair follicle's sensitivity to DHT. The follicles miniaturize (shrink), resulting in a shorter lifespan and the abnormal production of hair.
http://www.medicalnewstoday.com/articles/68082.php

Thanks to Monique for her thread in "Product Claims".

http://www.physicsforums.com/showthread.php?t=704520

Who knew?
Jamin2112
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#27
Oct16-13, 11:12 AM
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Quote Quote by Evo View Post
Caffeine. Seriously.

It seems DHT causes male pattern Baldness and caffeine reverses the effects (to some degree), I assume if it was significant it would be major news.



http://www.medicalnewstoday.com/articles/68082.php

Thanks to Monique for her thread in "Product Claims".

http://www.physicsforums.com/showthread.php?t=704520

Who knew?

Direct application to the scalp? Seriously?
Evo
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#28
Oct16-13, 11:20 AM
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Here's the study. (peer reviewed)

Abstract

Results  Significant growth suppression was found in hair follicles treated with 5 g/ml testosterone. This was counteracted by caffeine in concentrations of 0.001% and 0.005%. Moreover, caffeine alone led to a significant stimulation of hair follicle growth. These results were confirmed immunohistochemically by Ki-67 staining.
http://onlinelibrary.wiley.com/doi/1...119.x/abstract

And the article that references the study (not peer reviewed)

http://www.livestrong.com/article/550821-caffeine-dht/
Jamin2112
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#29
Oct16-13, 11:59 AM
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Quote Quote by Evo View Post
Here's the study. (peer reviewed)

Abstract



http://onlinelibrary.wiley.com/doi/1...119.x/abstract

And the article that references the study (not peer reviewed)

http://www.livestrong.com/article/550821-caffeine-dht/
How do I apply this at home? Isolate the caeffeine mollecules in my coffee and then somehow put them on my head?
Ryan_m_b
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#30
Oct16-13, 12:08 PM
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I don't know about where you live but in the UK shampoo containing caffeine is easy to find.
Evo
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#31
Oct16-13, 12:54 PM
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Garnier's Fructise is available everywhere, it seems. Your local drug store, walmart.

http://www.walmart.com/ip/Garnier-Fr....4-oz/20701261

All caffeine brands http://www.walmart.com/search/search...4&wl4=&veh=sem
Woopydalan
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#32
Oct16-13, 05:44 PM
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Quote Quote by SteamKing View Post
I don't know why the medical community is wasting time and resources on trivial problems like curing cancer or fighting infectious disease or birth defects when they should be confronting some really superficial issues like MPB.

Maybe that's what's lacking: people refer to the condition as 'male pattern baldness' when they should be referring to 'MPB'. That makes it sound like something which could strike anyone, anywhere, anytime. There could be an MPB Campaign, Walk for an MPB Cure, Raising MPB Awareness campaigns, the wearing of the Steel Gray Ribbon to show your Support to Find a Cure for MPB.
First time I ever lol'd on PF
mheslep
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#33
Oct31-13, 02:11 PM
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Quote Quote by Jamin2112 View Post
...

Is MPB just one of those natural aging processes for which there will never be a real fix?
Apparently a "real" medical "fix" is upon the hairline challenged. Expect another 5-10 years of development.

In PNAS:
Claire A. Higgins, James C. Chen, Jane E. Cerise, Colin A. B. Jahoda, and Angela M. Christiano
Feature Article: Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth
PNAS 2013 ; published ahead of print October 21, 2013

Quote Quote by Abstract
Growth of de novo hair follicles in adult skin occurs by a process known as hair neogenesis. One way of initiating neogenesis is to place dermal papillae isolated from the hair follicle in contact with an overlying epidermis where they reprogram the epidermis to adopt a follicular fate. This approach, however, has not been successful using cultured human dermal papilla cells in human skin because the cells lose their ability to induce hair growth after expansion in vitro. In this paper, we demonstrate that by manipulating cell culture conditions to establish three-dimensional papilla spheroids, we restore dermal papilla inductivity. We also use several systems biology approaches to gain a comprehensive understanding of the molecular mechanisms that underlie this regenerative process.
One of the researchers has a hair loss condition called alopecia areata:



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