- #1
jarroe
- 40
- 0
Cure for cancer lies in biotechnology and manipulating Virus’s??
What to kill a cancer cell without killing healthy cells around it? What’s the perfect candidate?
Something small to avoid the immune system. Something specific to the cancer cells.
Something lethal to the target cancer cells with minimal side effects..A genitcally altered virus.
Take a virus that the body cannot normally stop. Hep B.
Cut out the sequence of the DNA that codes for targeting the hepatocytes cell surface marker. That the limitation as of now. We don't know that yet...
The virus gains entry into the cell (Hepatocyte) by binding to an unknown receptor on the surface and being endocytosed in.
Replace that section of the DNA with a new section obtained from monoclonal antibody technology (Inject mouse with cancer cell to get antibody to it) developed from the cell surface markers/antigens on the target cancer cells. PCR technique to amplify the sample a billion fold and test to make sure all heb b virus has been 100% converted to the hep virus targeted for cancer cells. Inject it and let it do the rest. Instead of attacking liver cells it only seeks out cancer cells with the appropriate cell surface antigen.
Over simplified, but thoughts? Limitations?
What to kill a cancer cell without killing healthy cells around it? What’s the perfect candidate?
Something small to avoid the immune system. Something specific to the cancer cells.
Something lethal to the target cancer cells with minimal side effects..A genitcally altered virus.
Take a virus that the body cannot normally stop. Hep B.
Cut out the sequence of the DNA that codes for targeting the hepatocytes cell surface marker. That the limitation as of now. We don't know that yet...
The virus gains entry into the cell (Hepatocyte) by binding to an unknown receptor on the surface and being endocytosed in.
Replace that section of the DNA with a new section obtained from monoclonal antibody technology (Inject mouse with cancer cell to get antibody to it) developed from the cell surface markers/antigens on the target cancer cells. PCR technique to amplify the sample a billion fold and test to make sure all heb b virus has been 100% converted to the hep virus targeted for cancer cells. Inject it and let it do the rest. Instead of attacking liver cells it only seeks out cancer cells with the appropriate cell surface antigen.
Over simplified, but thoughts? Limitations?