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garytse86
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In the lecture handout it says "When cells are hyperpolarised the result is a depolarisation towards threshold." What does this mean?
garytse86 said:In the lecture handout it says "When cells are hyperpolarised the result is a depolarisation towards threshold." What does this mean?
GABA(A) receptors are a type of neurotransmitter receptor found in the brain. They are responsible for receiving and responding to the neurotransmitter GABA (gamma-aminobutyric acid). When GABA binds to these receptors, it can either cause hyperpolarization (inhibitory effect) or depolarization (excitatory effect) of the neuron.
Hyperpolarization is a process in which the membrane potential of a neuron becomes more negative, making it less likely to fire an action potential. This has an inhibitory effect on the brain, reducing the activity of neurons and promoting relaxation and calmness.
Depolarization is the process of making the membrane potential of a neuron more positive, increasing the likelihood of firing an action potential. This has an excitatory effect on the brain, promoting alertness and arousal.
The balance between hyperpolarization and depolarization in GABA(A) receptors can be influenced by a variety of factors, including the amount of GABA present, the number of GABA(A) receptors, and the activity of other neurotransmitters. Drugs and medications can also impact this balance.
Targeting GABA(A) receptors has been found to be effective in treating a variety of conditions such as anxiety, insomnia, and epilepsy. Understanding the mechanisms of these receptors can also lead to the development of new medications for these and other disorders.