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Making transgene dominant

by anubodh
Tags: dominant, transgene
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Dec6-13, 04:58 AM
P: 35
Can we make transgene dominant in the genetically engineered organism so that when it mates the offspring would have the same characteristics?
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Dec6-13, 06:56 AM
P: 7
Yes by insertion of the transgene in the germ cell
Dec6-13, 11:34 AM
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P: 1,402
Whether an allele of a gene acts in a dominant or recessive manner depends on the biochemistry of how the allele functions. In general, most loss-of-function alleles act in a recessive manner and most gain-of-function allele act in a dominant manner. Of course, there are many exceptions, such as dominant negative alleles which can interfere with the function of the wild type allele.

Here's a previous PF thread on the topic:

And here's a useful article on the subject:

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