How long does MCH stay elevated after beginning folate/b12 supplimentation?

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In summary, studies have shown that in iron and/or B12 deficiency, once levels of B12 and Ferritin have normalized, there is a significant improvement in all hematologic parameters. Reticulocytosis, an early sign of treatment effect, can be seen within 5-10 days. Oral and intramuscular B12 have been found to have similar effectiveness, but oral therapy may not be suitable for patients with pernicious anemia. However, certain preparations of B12 or high doses may still be effective in some cases.
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ihaveabutt
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In iron and/or b12 deficiency, once levels of b12 and Ferritin have normalized.
How long does it take for the MCH to return to normal ranges?
 
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ihaveabutt said:
In iron and/or b12 deficiency, once levels of b12 and Ferritin have normalized.
How long does it take for the MCH to return to normal ranges?

In this study of 60 patients with B12 deficiency, all hematologic parameters significantly improved from baseline over a 90 day interval. Reticulocytosis is an early sign of treatment effect which should appear between 5 and 10 days. This study compared oral and intramuscular B12 and found no significant difference. However, in pernicious anemia, a deficiency or lack of gastric intrinsic factor would normally preclude oral treatment, but oral therapy can be effective in some cases with certain preparations of B12 or in high doses.

www.ncbi.nlm.nih.gov/pubmed/14749150

www.keckmedicalcenterofusc.org/condition/document/96607
 
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1. How long does it take for MCH levels to normalize after starting folate and B12 supplementation?

The time it takes for MCH levels to normalize after starting folate and B12 supplementation varies depending on the individual's unique health and nutritional status. In general, it can take anywhere from a few weeks to a few months for MCH levels to return to a normal range. It is important to continue regular check-ups with your healthcare provider to monitor your MCH levels and determine the effectiveness of the supplementation.

2. Can MCH levels remain elevated despite taking folate and B12 supplements?

In some cases, MCH levels may remain elevated even with the use of folate and B12 supplements. This could be due to other underlying health conditions, such as liver disease or certain types of anemia. It is important to consult with a healthcare provider to determine the root cause of elevated MCH levels and develop a personalized treatment plan.

3. Is there a recommended dosage for folate and B12 supplements to lower MCH levels?

The recommended dosage for folate and B12 supplements to lower MCH levels may vary depending on the individual's age, health status, and the severity of MCH elevation. It is best to consult with a healthcare provider for personalized dosage recommendations based on your specific needs.

4. Can high doses of folate and B12 supplements cause MCH levels to decrease too quickly?

High doses of folate and B12 supplements may cause MCH levels to decrease too quickly, leading to complications such as anemia. It is important to follow the recommended dosage and have regular check-ups with a healthcare provider to monitor MCH levels and make necessary adjustments to the supplementation.

5. Are there any dietary or lifestyle changes that can help lower MCH levels?

In addition to folate and B12 supplements, making dietary and lifestyle changes can also help lower MCH levels. Consuming a diet rich in iron, vitamin B6, and vitamin B12 can support healthy MCH levels. Avoiding excessive alcohol consumption and quitting smoking can also help lower MCH levels. Consult with a healthcare provider for personalized recommendations based on your unique situation.

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