Pulmonary and Extra pulmonary Tuberculosis.

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In summary, the presence of intermittent fever episodes in tuberculosis can be attributed to the release of pyogenic cytokines during immune activation, which are known to have diurnal variations. Night sweats, while commonly associated with TB, are nonspecific and can occur in a variety of infections. Additionally, most TB infections in otherwise healthy individuals are asymptomatic, and only a small number develop symptoms. The mycobacterium that causes TB is more likely to cause fever in patients with disseminated infection.
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Manish7
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I have a query that why in tuberculosis intermitent episodes of fever occur every evening ?
Although the pyogenic cytokines(fever causing) released due to immune activation can cause fever but why in the evening only ??
Also, TB is associated with night sweats ,how can it occur in a patient of TB everyday ??
 
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  • #2
Manish7 said:
I have a query that why in tuberculosis intermitent episodes of fever occur every evening ?
Although the pyogenic cytokines(fever causing) released due to immune activation can cause fever but why in the evening only ??
Also, TB is associated with night sweats ,how can it occur in a patient of TB everyday ??

Fevers in general tend to be diurnal with maximums occurring in the early evening. TB and lymphoma tend to be identified more with these symptoms but there are a variety of other causes. Interleuken 1 (IL1), tumor necrosis factor (TNF) and interferon-[itex]\alpha[/itex] release appear to be influenced by the circadian regulation by the hypothalamus. Nightsweats likewise are nonspecific and associated with bacteremia. You seem to believe that these symptoms are unique to TB and occur "every day". In fact, most TB infections in otherwise healthy people are asymptomatic. The number of people who test positive for TB is much larger than the number who become ill in developed countries. The mycobacterium that causes TB is particularly pyrogenic in those patients with disseminated (extrapulmonary) infection.

http://www.ncbi.nlm.nih.gov/books/NBK324/

http://www.ncbi.nlm.nih.gov/pubmed/9215292
 
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What is pulmonary tuberculosis?

Pulmonary tuberculosis is a contagious bacterial infection that primarily affects the lungs. It is caused by the bacteria Mycobacterium tuberculosis and can spread through the air when an infected person coughs, sneezes, or speaks.

What are the symptoms of pulmonary tuberculosis?

The most common symptoms of pulmonary tuberculosis include persistent coughing (sometimes with blood), chest pain, fatigue, fever, night sweats, and weight loss. However, some people may not experience any symptoms at all.

What is extra pulmonary tuberculosis?

Extra pulmonary tuberculosis is a form of tuberculosis that affects parts of the body outside of the lungs. This can include the lymph nodes, bones and joints, central nervous system, and reproductive organs. It is less common than pulmonary tuberculosis, but can still be serious if left untreated.

How is tuberculosis diagnosed?

Tuberculosis can be diagnosed through a series of tests, including a skin test, blood test, chest X-ray, and sputum culture. These tests can identify the presence of the bacteria and determine if a person has an active infection.

Is tuberculosis treatable?

Yes, tuberculosis is treatable with a combination of antibiotics. Treatment typically lasts for 6-9 months and is highly effective in curing the infection. However, it is important for patients to complete the full course of treatment to prevent the bacteria from developing resistance to the antibiotics.

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