Reversal of Spinal Cord Damage using Stem Cell Therapy

In summary, the conversation discussed the recent 60mins TV spot featuring Hans S. Keirstead's research on reversing spinal cord damage in rats using human embryo stem cells. This approach may bring about a potential therapy for humans paralyzed by spinal cord damage, with human clinical trials potentially being approved as early as next year. The findings were published in the Journal of Neuroscience in May 2005, showing that transplantation of human embryonic stem cell-derived oligodendrocyte progenitor cells promotes remyelination and improves motor function in rats with spinal cord injuries. However, the effectiveness of this treatment decreases after 10 months of injury. This research demonstrates the possibility of using hESCs to create functional OPCs and their potential in treating
  • #1
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Did anyone happen to catch the 60mins TV spot of Hans S. Keirstead last night?

His research showing reversing spinal cord damage in rats using human embryo stem cells is compelling. Brings this approach to humans paralyzed by spinal cord damage, closer to reality. Human clinical trials may be approved as early as next year.

His findings were published in Journal of Neuroscience last May 2005

Hans S. Keirstead, Gabriel Nistor, Giovanna Bernal, Minodora Totoiu, Frank Cloutier, Kelly Sharp, and Oswald Steward
Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury
J. Neurosci., May 2005; 25: 4694 - 4705 ; doi:10.1523/JNEUROSCI.0311-05.2005

Demyelination contributes to loss of function after spinal cord injury, and thus a potential therapeutic strategy involves replacing myelin-forming cells. Here, we show that transplantation of human embryonic stem cell (hESC)-derived oligodendrocyte progenitor cells (OPCs) into adult rat spinal cord injuries enhances remyelination and promotes improvement of motor function. OPCs were injected 7 d or 10 months after injury. In both cases, transplanted cells survived, redistributed over short distances, and differentiated into oligodendrocytes. Animals that received OPCs 7 d after injury exhibited enhanced remyelination and substantially improved locomotor ability. In contrast, when OPCs were transplanted 10 months after injury, there was no enhanced remyelination or locomotor recovery. These studies document the feasibility of predifferentiating hESCs into functional OPCs and demonstrate their therapeutic potential at early time points after spinal cord injury.
 
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  • #2
Yes, I did view the program and it was very interesting.
 
  • #3
Indeed, I didn't realize we were that close to implementing a therapy that may repair the nerves in the spinal chord and allow para and quadrapalegic individuals a means of acquiring mobility.
 

1. How does stem cell therapy reverse spinal cord damage?

Stem cell therapy involves injecting specialized cells, known as stem cells, into the damaged area of the spinal cord. These cells can differentiate into various types of cells, including neural cells, which can help repair and regenerate damaged nerve tissue in the spinal cord.

2. What types of stem cells are used in this therapy?

The most commonly used type of stem cells for spinal cord damage are mesenchymal stem cells (MSCs). These stem cells can be obtained from various sources, such as bone marrow, adipose tissue, or umbilical cord blood.

3. Is stem cell therapy a permanent solution for reversing spinal cord damage?

Currently, there is no permanent solution for reversing spinal cord damage. While stem cell therapy has shown promising results in improving motor function and sensation in patients with spinal cord injuries, it is still a relatively new and developing treatment. Long-term studies are needed to determine the effectiveness and potential long-term benefits of this therapy.

4. Are there any potential risks or side effects associated with stem cell therapy for spinal cord damage?

As with any medical procedure, there are potential risks and side effects associated with stem cell therapy for spinal cord damage. These may include infection, bleeding, and allergic reactions. Additionally, there is a risk of the injected stem cells not behaving as intended and potentially causing harm. It is important to discuss the potential risks and benefits with a healthcare professional before undergoing this treatment.

5. Is stem cell therapy for spinal cord damage covered by insurance?

Currently, stem cell therapy for spinal cord damage is not covered by insurance in most cases. This is because it is still considered an experimental treatment and there is limited research on its long-term effectiveness. However, some clinical trials may cover the cost of the therapy. It is important to check with your insurance provider and healthcare professional for more information.

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