What is the role of thromboplastin in haemolysis and coagulation?

  • Thread starter Cheman
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In summary, there are multiple pathways involved in the process of blood coagulation. Thromboplastin, which is produced by damaged tissues, can act as a catalyst to convert prothrombin into thrombin. However, prothrombin activator, which results from thromboplastin and other factors, can also perform this conversion. Platelets play a critical role in this process, releasing factors and triggering a reflex of vasoconstriction when tissue is damaged. Overall, both the textbook and internet references are accurate in their descriptions of the coagulation process.
  • #1
Cheman
235
1
My textbook says that thromboplastin which is produced by damaged tissues acts as the catalyst to convert prothrombin into thrombin. However, I have seen on the internet references to a Prothrombin activator being the catalyst and that this results from thromboplastin and other factors. Which is true? What really does happen?
Thanks.
 
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  • #2
Coagulatuion may begin from any of the coagulation factors from different pathway depending on the extent of damage and time of the signalling. Both the test book and the internet references are more or less rigth. http://www.biocarta.com/pathfiles/h_intrinsicPathway.asp

thromboplastin: an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot

prothrombin - a protein in blood plasma that is the inactive precursor of thrombin

http://www.thefreedictionary.com/coagulation factor
 
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  • #3
So, which is it which converts prothrombin to thrombin? Thromboplastin or prothrombin activator? Thanks.
 
  • #4
Also, apparently platelet factors are released when platelets lyse or burst. hy do they burst?
 
  • #5
Cheman said:
So, which is it which converts prothrombin to thrombin? Thromboplastin or prothrombin activator?

Both compound convert prothrombin but using different pathways.

http://www.labtestsonline.org/images/coag_cascade.pdf

Cheman said:
apparently platelet factors are released when platelets lyse or burst. hy do they burst?

Again different pathways comes into play but briefly you have antibodies, complement and bacterial factors.
 
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  • #6
Why do they burst?
Also, what causes the reflex of vascoconstriction when we are cut?
 
  • #7
Platelets release their granula upon activation, they don't actually burst. The vascoconstriction is mediated by factors released by the damaged tissue and the activated platelets.
 

1. What is haemolysis and how does it occur?

Haemolysis refers to the destruction or breakdown of red blood cells. This can occur due to various factors such as physical trauma, infections, toxins, or immune reactions. It can also occur as a result of certain medical conditions like sickle cell disease or hereditary spherocytosis.

2. What are the symptoms of haemolysis and coagulation disorders?

The symptoms of haemolysis include fatigue, weakness, pale skin, shortness of breath, and jaundice. Coagulation disorders can cause excessive bleeding or bruising, prolonged bleeding from wounds, nosebleeds, and heavy menstrual bleeding.

3. What are the common causes of coagulation disorders?

Coagulation disorders can be caused by inherited genetic mutations, liver disease, vitamin K deficiency, certain medications, and autoimmune disorders. They can also be acquired due to factors like advanced age, pregnancy, or surgery.

4. How are haemolysis and coagulation disorders diagnosed?

Haemolysis can be diagnosed through a blood test that measures the levels of red blood cells and their breakdown products. Coagulation disorders can be diagnosed through a blood test that measures the clotting ability of the blood and the levels of clotting factors.

5. What are the treatment options for haemolysis and coagulation disorders?

The treatment for haemolysis depends on the underlying cause. In some cases, it may resolve on its own, while in others, it may require specific treatment such as blood transfusions or medications to suppress the immune system. Coagulation disorders can be managed with medications to prevent excessive bleeding and promote blood clotting, as well as with lifestyle changes such as avoiding certain activities that may increase the risk of bleeding.

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