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Interesting fact:
The liver is an organ that filters blood that comes from the digestive tract, blood comes in one side and goes out another.
Researchers wondered whether pathologies could arise when the wrong 'type' of blood enters the liver, fresh blood might have certain cell-mediators in them that alter gene expression and thus regulate glycolysis/gluconeogenesis.
So they change the 'type' of blood that enters the liver, by rerouting certain bloodvessels. They did not find any difference in gene expression of target genes.
BUT pathologies are known where liver failure develops when the right heart ventricle is unable to pump blood sufficiently, causing blood to return to the liver.
So the researchers looked at gene expression when blood was entering the liver from the wrong direction, AND! it was different!
Strange that wrong blood entering from one side doesn't have an effect, but wrong blood entering from the other side does :)
The liver is an organ that filters blood that comes from the digestive tract, blood comes in one side and goes out another.
Researchers wondered whether pathologies could arise when the wrong 'type' of blood enters the liver, fresh blood might have certain cell-mediators in them that alter gene expression and thus regulate glycolysis/gluconeogenesis.
So they change the 'type' of blood that enters the liver, by rerouting certain bloodvessels. They did not find any difference in gene expression of target genes.
BUT pathologies are known where liver failure develops when the right heart ventricle is unable to pump blood sufficiently, causing blood to return to the liver.
So the researchers looked at gene expression when blood was entering the liver from the wrong direction, AND! it was different!
Strange that wrong blood entering from one side doesn't have an effect, but wrong blood entering from the other side does :)