Chromatin remodelling factors?

Thread starter hivesaeed4
Start date Nov 29, 2012
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In summary, chromatin remodelling factors are proteins involved in the dynamic changes of DNA packaging that allow for gene expression and replication. They work by interacting with histone proteins and can both alter their positioning and modify them directly. These factors play a critical role in regulating the accessibility of DNA and can contribute to diseases like cancer and neurological disorders if dysregulated. They can also be targeted for therapeutic purposes, but more research is needed to fully understand their functions and potential in treating certain disorders.

Nov 29, 2012

hivesaeed4

I'd like to know what is their main purpose. Is it to regulate transcription by modifying chromatin?

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Dec 6, 2012

mishrashubham

hivesaeed4 said:

I'd like to know what is their main purpose. Is it to regulate transcription by modifying chromatin?

Yep, Chromatin remodelling is mainly for the purpose of regulation of transcription and hence gene expression.

1. What are chromatin remodelling factors?

Chromatin remodelling factors are proteins that play a critical role in regulating the structure and accessibility of DNA within the cell. They are involved in the process of chromatin remodelling, which refers to the dynamic changes in the packing of DNA that allow for gene expression and DNA replication.

2. How do chromatin remodelling factors work?

Chromatin remodelling factors work by interacting with histone proteins, which are responsible for packaging DNA into a compact structure. They can alter the positioning of these histones, making the DNA more or less accessible to other proteins involved in gene expression. Additionally, they can also directly modify the histones themselves, influencing the overall structure of chromatin.

3. What is the role of chromatin remodelling factors in gene expression?

Chromatin remodelling factors play a crucial role in gene expression by regulating the accessibility of DNA. They can either promote or inhibit the binding of transcription factors and other proteins involved in gene expression, ultimately influencing whether a gene is turned on or off.

4. How do chromatin remodelling factors contribute to disease?

Chromatin remodelling factors have been implicated in a variety of diseases, including cancer and neurological disorders. Dysregulation of these factors can lead to abnormal gene expression, which can result in uncontrolled cell growth or impaired brain function.

5. Can chromatin remodelling factors be targeted for therapeutic purposes?

Yes, chromatin remodelling factors have been identified as potential therapeutic targets for certain diseases. By targeting these factors, it may be possible to modulate gene expression and potentially treat or prevent certain disorders. However, more research is needed in this area to understand the specific roles and mechanisms of different chromatin remodelling factors in different diseases.