How old is Brooke, the girl who never ages?

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In summary, Brooke, who is in her mid-teens, was born with a disability that caused stunted growth. Her mother has been taking care of her since she was a baby by restricting her growth so she can physically care for her.
  • #1
junglebeast
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This is pretty fascinating..

Article:
http://abcnews.go.com/print?id=7880954

Brooke rides in a stroller while her mom shops for clothes in the infant sections of department stores near their home in a Baltimore suburb. That Brooke is in her mid-teens is so mind-boggling that if another mother with a toddler asks Greenberg how old Brooke is, she usually doesn't try to explain.

"My system always has been to turn years into months," Greenberg said. "So, if someone asked today, I might say, she's 16 months old."

"Brooke's hair and her nails are the only two things that grow"Picture:
http://abcnews.go.com/2020/popup?id=7881955
 
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  • #2
I've read about http://en.wikipedia.org/wiki/Ashley_Treatment" [Broken], where parents intentionally restricted the growth of a disabled child so they could physically care for her. The original article I read about this case was in a publication about disability issues at our local wheelchair mechanic while our P was getting his chair fixed up.

Though my spouse usually does all physical care for our son when he's available, fortunately as our P gets older, his younger brother is able to help me get him in and out of his chair so I can perform most functions to some degree of sufficiency. The care factor is, however, something that all parents of disabled children (regardless of the level of disability) think about as their children (and themselves) age, and while we want M to have a good relationship with his older brother we also don't want him to feel unnecessarily tied as a caretaker.

This case is interesting because it's a natural case of stunted growth... and yes, let's face the facts that stunted growth helps in being able to provide basic care to a disabled child -- indeed due to high muscle tone, etc, our P at age 16 is probably about 75-80 lbs (despite a typical teenage appetite!), not the average 140 lbs... and this makes caring for him in some ways easier (before I was expecting I would get him out of his chair myself).
 
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  • #3
PGP: That is a very interesting point that I had never considered before. I have an older sister (I believe she is ~38) with Rett Syndrome.

It is precisely this aspect (the weight aspect) that made it impossible for her to live at home anymore. In her late teens she eventually lost near all of her self mobility.

Though I could probably never bring myself to intentionally stunt my own child's growth, I also cannot yet condemn the idea. After seeing the kinds of horrors my poor sister has gone through due to negligent group-home workers, I would have to at least consider all possible solutions that would enable me to maintain sole care.
 
  • #4
physics girl phd said:
This case is interesting because it's a natural case of stunted growth...
This even goes farther than that: they gave her growth hormones, but her body gave no response at all. This indeed is a very interesting medical case, why did her development stop at the age of 6 months?
 
  • #5
Monique said:
why did her development stop at the age of 6 months?

I'm really curious as to why she was ever born in the first place. I would have expected that her condition should have prevented her from developing to term, let alone to 6-month size.
 
  • #6
Danger said:
I'm really curious as to why she was ever born in the first place. I would have expected that her condition should have prevented her from developing to term, let alone to 6-month size.
There were prenatal growth problems, where one month she was below the growth curve but the next month she had caught up her growth. Of course I can only speculate, but there could have been an incident at 6 months of age that triggered the stop in development (think for instance a virus infection that put a strain on her system).

There are cases known where mono-zygotic or di-zygotic twins both carry the same mutation(s), but disease only manifests in one of the twin. http://qjmed.oxfordjournals.org/cgi/content/abstract/97/4/199" [Broken]

Another speculation is that in other organisms there are different developmental stages that each require specific triggers to start that program, a defect in such a trigger would cause a developmental stage to be repeated or skipped. Maybe there is such a switch in humans that causes development past her age, but I don't have any evidence for that.
 
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  • #7
I'm curious how the normal aging process would be changed as she grows into old age. Would her cells deteriorate giving her gray hair and wrinkly skin while staying in the shape of an infant, or would she essentially stay young forever? There's no fundamental reason why an organism can't live forever. To be honest, though, I don't think we'll get to see...I expect her to die young as a result of this for some reason.
 
  • #8
junglebeast said:
I'm curious how the normal aging process would be changed as she grows into old age. Would her cells deteriorate giving her gray hair and wrinkly skin while staying in the shape of an infant, or would she essentially stay young forever? There's no fundamental reason why an organism can't live forever. To be honest, though, I don't think we'll get to see...I expect her to die young as a result of this for some reason.

she is still subject to DNA deterioration that over time breaks down due to things like free radicals that consistently destroy our DNA and morph it...

basically no living organism can ever "live" forever (in that sense)... unless there was some artificial means to do so ("copying" to computers, replacement of body parts/organs, etc.)
 
  • #9
bleedblue1234 said:
she is still subject to DNA deterioration that over time breaks down due to things like free radicals that consistently destroy our DNA and morph it...

basically no living organism can ever "live" forever (in that sense)... unless there was some artificial means to do so ("copying" to computers, replacement of body parts/organs, etc.)

There are plenty of organisms that don't undergo aging; they are said to have biological immortality (http://en.wikipedia.org/wiki/Biological_immortality). Of course, they're not immortal in the common sense of the word because of injury, predation, and the like.
 
  • #10
bleedblue1234 said:
she is still subject to DNA deterioration that over time breaks down due to things like free radicals that consistently destroy our DNA and morph it...

basically no living organism can ever "live" forever (in that sense)... unless there was some artificial means to do so ("copying" to computers, replacement of body parts/organs, etc.)
Living organisms have been around for a very, very long time (in a sense we've already been living forever). There will be opportunities in the future that will allow us to lead a healthy life for a much longer time.

Having an altered metabolism could mean she ages differently, but only time can tell.
 
  • #11
The thing that bothers me looking at the photos is that the family is still dressing her like an infant even though she's 16 years old. Yes, she may have an infant-sized body, but she isn't an infant. If she isn't growing, surely it wouldn't be cost-prohibitive to have a few outfits custom sewn to fit her that are more age-appropriate for the sake of dignity.

If growth hormone had no effect, it sounds like it must be related to the growth hormone receptor or a downstream signalling event that's disrupted. That they say she has had some growth, but not consistent and not all parts of her body are coordinated in their growth leads me to think it's more likely part of the signaling cascade, maybe an insufficient production of something, but not completely absent.
 
  • #12
Moonbear said:
The thing that bothers me looking at the photos is that the family is still dressing her like an infant even though she's 16 years old. Yes, she may have an infant-sized body, but she isn't an infant. If she isn't growing, surely it wouldn't be cost-prohibitive to have a few outfits custom sewn to fit her that are more age-appropriate for the sake of dignity.

If growth hormone had no effect, it sounds like it must be related to the growth hormone receptor or a downstream signalling event that's disrupted. That they say she has had some growth, but not consistent and not all parts of her body are coordinated in their growth leads me to think it's more likely part of the signaling cascade, maybe an insufficient production of something, but not completely absent.

Well, from the article,

Brooke Greenberg is the size of an infant, with the mental capacity of a toddler.

Hard to say what I would do in that situation (as a parent), but with a kid who looks like a baby and has limited mental capability, it might be strange to dress her like a teenager. In fact it might look sort of creepy to those who don't know her medical condition.
 
  • #13
Moonbear said:
If she isn't growing, surely it wouldn't be cost-prohibitive to have a few outfits custom sewn to fit her that are more age-appropriate for the sake of dignity.
It appears she still needs diapers. Trying to dress her in grownup clothes seems both pointless and impractical.
 
  • #14
Moonbear said:
The thing that bothers me looking at the photos is that the family is still dressing her like an infant even though she's 16 years old. Yes, she may have an infant-sized body, but she isn't an infant. If she isn't growing, surely it wouldn't be cost-prohibitive to have a few outfits custom sewn to fit her that are more age-appropriate for the sake of dignity.

If growth hormone had no effect, it sounds like it must be related to the growth hormone receptor or a downstream signalling event that's disrupted. That they say she has had some growth, but not consistent and not all parts of her body are coordinated in their growth leads me to think it's more likely part of the signaling cascade, maybe an insufficient production of something, but not completely absent.

My roommates have a 5 year old disabled son. He has the body of an 18 month old, and the mind of a 6 month old. We still refer to him as "the baby."

I think you put far too much emphasis on chronological age, as if it's actually meaningful in the case of developmental delays.
 
  • #15
Jack21222 said:
My roommates have a 5 year old disabled son. He has the body of an 18 month old, and the mind of a 6 month old. We still refer to him as "the baby."

I think you put far too much emphasis on chronological age, as if it's actually meaningful in the case of developmental delays.

It would be folly to pretend that their son was "merely" a "normal" 6 month old. Your friend's son is not a baby.

To do right by him, he should be treated as what he is: a 5-year-old with a condition that gives him the body of an 18-month-old and the mental capacity of a 6-month-old.
 
  • #16
junglebeast said:
There's no fundamental reason why an organism can't live forever.

This is very true. There is no reason why we can't just grow new cells after the old ones die or replace damaged/mutated cells. A healthy persons liver regenerates itself about every 6 months, there is no reason why this mechanism can not be shared with all other cells in the body. I've even read stories about people that start to regrow fingers or appendages after they lose them in a near death experience.

Deepak Chopra must be having a field day with this.
 
  • #17
Topher925 said:
This is very true. There is no reason why we can't just grow new cells after the old ones die or replace damaged/mutated cells. A healthy persons liver regenerates itself about every 6 months, there is no reason why this mechanism can not be shared with all other cells in the body.
By what rationale do you make this claim? It seems there are plenty of reasons.
 
  • #18
DaveC426913 said:
By what rationale do you make this claim? It seems there are plenty of reasons.

I think he meant that there is no fundamental reason why cells in one organ could not possibly regrow themselves if it was shown that cells in a different organ could regrow themselves.
 
  • #19
DaveC426913 said:
It would be folly to pretend that their son was "merely" a "normal" 6 month old. Your friend's son is not a baby.

To do right by him, he should be treated as what he is: a 5-year-old with a condition that gives him the body of an 18-month-old and the mental capacity of a 6-month-old.

There's a difference between "treating him as a normal 6 month old" and calling him a "baby."

He can't eat solid foods (drinks formula, with occasional "real" meals of apple sauce and the like), he needs a diaper, can't walk, can't talk, doesn't respond to his own name... sounds like a baby to me.

Of course they treat him as a 5 year old with a special condition. He goes to Maryland School for the Blind, where they have a special PT/OT program for him, and he has many doctors appointments. But other than that? He's treated mostly like one would treat a baby. I don't know how else you can treat a kid who can't talk, doesn't know his own name, and his method of playing with a toy is either chewing on it or smacking it.
 
  • #20
Jack21222 said:
There's a difference between "treating him as a normal 6 month old" and calling him a "baby."

He can't eat solid foods (drinks formula, with occasional "real" meals of apple sauce and the like), he needs a diaper, can't walk, can't talk, doesn't respond to his own name... sounds like a baby to me.

I don't know how else you can treat a kid who can't talk, doesn't know his own name, and his method of playing with a toy is either chewing on it or smacking it.
i.e. if it walks like a duck, we might as well treat it like a duck.

This is how people are misunderstood and marginalized.

Jack21222 said:
Of course they treat him as a 5 year old with a special condition.
Good. And so should you.

Which is why I disagree with your initial statement "I think you put far too much emphasis on chronological age, as if it's actually meaningful in the case of developmental delays."
 

1. How is it possible for Brooke to never age?

Brooke's condition is known as "agelessness" and is considered extremely rare. It is believed that her cells have a unique ability to constantly regenerate, preventing the natural aging process.

2. How long has Brooke been alive?

It is difficult to determine exactly how long Brooke has been alive since she does not age like a typical human. However, based on her physical appearance and estimated birth date, it is believed that she is over 100 years old.

3. Is there any scientific evidence to support Brooke's agelessness?

While Brooke's condition has not been extensively studied, there have been some studies on similar cases of agelessness in animals. These studies have shown that certain species have the ability to regenerate cells and potentially live longer without showing signs of aging.

4. Does Brooke have any health problems or limitations due to her agelessness?

It is not known if Brooke experiences any health problems or limitations due to her agelessness. However, it is possible that she may have a weaker immune system and be more susceptible to certain illnesses.

5. Can Brooke's agelessness be reversed or replicated in other humans?

At this time, there is no known way to reverse or replicate Brooke's agelessness in other humans. More research and understanding of her condition is needed before any potential treatments or cures can be developed.

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