Do we know why mosquitoes do not transmit the HIV-AIDS virus?

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In summary, research and epidemiological data confirm that mosquitoes are not capable of transmitting HIV. The virus dies almost instantly in the mosquito's body and cannot be injected into a new host through the insect's saliva. This is due to the fact that HIV can only survive in human cells and does not reproduce inside of mosquitoes like other viruses. The epidemiology of AIDS in areas with high mosquito populations also supports this, as there is no disproportionate number of cases among children and elderly individuals. While rare cases may exist, the chances of HIV transmission through mosquito bites are extremely low.
  • #1
daniel6874
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Do we know why mosquitoes do not transmit the HIV-AIDS virus?
 
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  • #2


hi,
have a look here..
http://www.rci.rutgers.edu/~insects/aids.htm [Broken]
 
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  • #3


Rajini said:
hi,
have a look here..
http://www.rci.rutgers.edu/~insects/aids.htm [Broken]

This is an interesting article but the theoretical impossibility of transmission would also apply to the virus that causes yellow fever. Not all viruses are alike, but there is no indication why the AIDS virus would be any less transmissible than other mostquito-borne viruses.

I completely accept that AIDS is not mosquito-transmitted. I just don't understand what sets the AIDS (retrovirus, I think) pathogen apart from other nm-sized organisms. Thanks.
 
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  • #4


Yellow fever is able to infect mosquito cells and replicate inside of mosquitoes, an ability that HIV has not evolved. Perhaps this has to do with the fact that HIV infects a much more specific class of cells than yellow fever.
 
  • #5


Rajini said:
hi,
have a look here..
http://www.rci.rutgers.edu/~insects/aids.htm [Broken]

it is the second mechanism that seems to be an unknown. how would you go about proving this?
 
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  • #6


Proton Soup said:
it is the second mechanism that seems to be an unknown. how would you go about proving this?

"2. In the second mechanism, a mosquito would ...feed on an HIV carrier and be interrupted after it had successfully drawn blood. Instead of resuming...on its original host, the mosquito would select an AIDS-free person to complete the meal... equine infectious anemia is transmitted to horses by biting flies in this manner."
____

I don't understand what you are suggesting should be proved. The article says these mechanisms are used in other settings and not used in HIV transmission. We don't have to prove it--it doesn't happen. I gather that this mechanism has been shown in equine anemia context. Sorry if I am misunderstanding your question.
 
  • #7


daniel6874 said:
"2. In the second mechanism, a mosquito would ...feed on an HIV carrier and be interrupted after it had successfully drawn blood. Instead of resuming...on its original host, the mosquito would select an AIDS-free person to complete the meal... equine infectious anemia is transmitted to horses by biting flies in this manner."
____

I don't understand what you are suggesting should be proved. The article says these mechanisms are used in other settings and not used in HIV transmission. We don't have to prove it--it doesn't happen. I gather that this mechanism has been shown in equine anemia context. Sorry if I am misunderstanding your question.

how do you know that?
 
  • #8


Proton Soup said:
how do you know that?

In theory mosquitoes can be capable of transmit HIV, if you look really deep probably you can find a rare case were this happens. One evidence that this are not common is the epidemiological data of African countries, if this kind of transmission occurs the epidemic data will be far more worst.
 
  • #9


This is very clear, from the epidemiology alone, and from basic biology. To ask this shows a fundamental lack of understanding as to how insect-borne disease DOES find a transmissible intermediary.

Staf.ord said:
Ways in Which HIV Is NOT Transmitted
Insect bites
HIV is not transmitted by mosquitoes, flies, ticks, fleas, bees or wasps. If a bloodsucking insect bites someone with HIV, the virus dies almost instantly in the insect's stomach (as it digests the blood). HIV can only live in human cells.

Mosquitoes cannot transmit HIV for two reasons:

•The mosquito draws blood and injects saliva. The blood from one person is not injected into the mosquito's next victim.
•HIV dies in the mosquito's body. People sometimes are confused because malaria actually reproduces inside the mosquito's digestive tract, using the insect as part of its life cycle. HIV does not.
These facts are confirmed by looking at infection patterns. In areas where mosquitoes are common and where HIV is prevalent, the distribution of AIDS cases in the population is not different from other areas. If mosquitoes transmitted HIV, they would be seeing a disproportionate number of children and elderly infected in those areas.
http://www.sfaf.org/aids101/transmission.html

Here is some research that will allow you to understand which insects make proper vectors for disease, and further research can explain why: http://www.cals.ncsu.edu/course/ent425/text18/humanvectors.html

I doubt you could find a single case of mosquito-borne HIV that you could possibly confirm, however close you look. HIV requires more than a single virion to cause infection.
 
  • #10


AlexB2010 said:
In theory mosquitoes can be capable of transmit HIV, if you look really deep probably you can find a rare case were this happens. One evidence that this are not common is the epidemiological data of African countries, if this kind of transmission occurs the epidemic data will be far more worst.

that would really depend on the rate of transmission.

nismaratwork said:
This is very clear, from the epidemiology alone, and from basic biology. To ask this shows a fundamental lack of understanding as to how insect-borne disease DOES find a transmissible intermediary.


http://www.sfaf.org/aids101/transmission.html

Here is some research that will allow you to understand which insects make proper vectors for disease, and further research can explain why: http://www.cals.ncsu.edu/course/ent425/text18/humanvectors.html

I doubt you could find a single case of mosquito-borne HIV that you could possibly confirm, however close you look. HIV requires more than a single virion to cause infection.

that's the trouble with epidemiology. if it's a rare event, you probably won't see the outliers, or if you do, you'll just reject them as outliers.
 
  • #11


Proton Soup said:
that would really depend on the rate of transmission.



that's the trouble with epidemiology. if it's a rare event, you probably won't see the outliers, or if you do, you'll just reject them as outliers.

In the context of what is a massive worldwide pandemic, yes that can happen. The nature of HIV infection, and the feeding habits of mosquito added to the epidemiology makes it pretty much impossible however. I hear a lot about the use of needles in IV drug use, but in that case blood is drawn into the chamber of the syringe first, not just a light coating on the needles. Remember also, that sharing needles tends to be a repeated event, allowing for infection, not just a miraculous mosquito. A mosquito's saliva is going to rapidly digest HIV (just protein to the bug) and the feeding apparatus is retracting and cleaned with saliva.

Maybe if a mosquito fed on someone with full-blown AIDS and a massive viral count, then flew directly into an open wound on another body seconds after feeding you COULD be infected... even then I wouldn't bet on it.
 
  • #12


Proton Soup said:
that would really depend on the rate of transmission.
that's the trouble with epidemiology. if it's a rare event, you probably won't see the outliers, or if you do, you'll just reject them as outliers.

Biology is still so much diverse, the fact that you find a single case doesn’t means this happens in a significant number of cases.
Impossible? No. Improbable? Yes. Neglect able? Yes.
 
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  • #13


i'm sure it's an extremely low probability. but it would still make me think twice in certain social situations, as i am a mosquito magnet.
 
  • #14


Proton Soup said:
i'm sure it's an extremely low probability. but it would still make me think twice in certain social situations, as i am a mosquito magnet.

Buy some lottery tickets… you will have better chances.
 
  • #15


Proton Soup said:
i'm sure it's an extremely low probability. but it would still make me think twice in certain social situations, as i am a mosquito magnet.

Obviously there is no study that is going to say, "this is impossible", but Proton Soup: it's basically impossible. It just is not that easy to be infected with HIV! You are essentially talking about a near-microscopic needle stick, but one that has been cleansed with enzyme-rich saliva.

Maybe we need to look away from the bugs, and to the rate of transmission from REAL needle-sticks:

CCohs Canada said:
What are the hazards of needlestick injuries?

Accidental punctures by contaminated needles can inject hazardous fluids into the body through the skin. There is potential for injection of hazardous drugs, but injection of infectious fluids, especially blood, is by far the greatest concern. Even small amounts of infectious fluid can spread certain diseases effectively.

Accidental injection of blood-borne viruses is the major hazard of needlestick injuries, especially the viruses that cause AIDS(the HIV virus), hepatitis B, and hepatitis C.

The risk of infection after exposure to infected blood varies by bloodborne pathogen. The risk of transmission after exposure to HIV-infected blood is about 0.3%, whereas it is estimated to be up to 100 times greater for hepatitis B virus (30%) and could be as high as 10% for hepatitis C virus.

http://www.ccohs.ca/oshanswers/diseases/needlestick_injuries.html
http://www.avert.org/needlestick.htm

Note the risk factors:

Avert said:
Certain specific factors may mean a percutaneous injury carries a higher risk, for example:

A deep injury
Late-stage HIV disease in the source patient
Visible blood on the device that caused the injury
Injury with a needle that had been placed in a source patient's artery or vein

So, if you're in Africa working in palliative care for people dying of AIDS with massive viral counts, you need a mosquito with a trocar for a proboscis, and glistening red as it fails to clean itself and them plunges into you. You will die of malaria, or dengue, or old age and paper cuts from Alex's lottery tickets before you contract HIV from a mosquito.
 

1. Why do mosquitoes not transmit the HIV-AIDS virus?

The reason mosquitoes cannot transmit the HIV-AIDS virus is because the virus is not able to replicate inside a mosquito. Mosquitoes do not have the necessary enzymes and receptors for the virus to infect and reproduce within their bodies. Additionally, the virus cannot survive in the mosquito's gut due to the low pH levels.

2. Can mosquitoes become infected with the HIV-AIDS virus?

No, mosquitoes cannot become infected with the HIV-AIDS virus. As mentioned before, the virus cannot replicate or survive in the mosquito's body. Therefore, even if a mosquito bites a person with HIV, it will not become infected and cannot transmit the virus to others.

3. Are there any other insects that can transmit the HIV-AIDS virus?

No, there are no other insects that can transmit the HIV-AIDS virus. Mosquitoes are the only insects that have been extensively studied and proven to not be able to transmit the virus. Other insects, such as bed bugs and fleas, also do not have the ability to transmit the virus.

4. Can mosquitoes transmit any other blood-borne diseases?

Yes, mosquitoes are known to transmit various blood-borne diseases such as malaria, dengue fever, and yellow fever. These diseases are caused by different types of viruses and parasites that are able to infect and reproduce within the mosquito's body.

5. Is there a possibility that mosquitoes could evolve to transmit the HIV-AIDS virus in the future?

There is currently no evidence or scientific research indicating that mosquitoes could evolve to transmit the HIV-AIDS virus. The virus has been extensively studied and it is highly unlikely that it would suddenly gain the ability to replicate and survive in mosquitoes. However, as with any virus, ongoing research is needed to understand and monitor any potential changes or mutations in the virus.

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