For those of you with the Alberts text

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In summary, in G1 phase, a pre-replication complex is formed on each origin, containing proteins such as ORC, Cdc6p, Cdt1p, and MCM. At the G1-S boundary, CDK and a second kinase, Cdc7p-Dbf4p, activate the pre-RC to initiate DNA replication. The ORC, which is present throughout the cell cycle, serves as a landing pad for the assembly of the pre-RC. The second kinase's specific name is Cdc7p-Dbf4p and it is responsible for phosphorylating ORC.
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For those of you with the Alberts text...

Page 999, top paragraph:

"Once the pre-RC has been assembled in G1, the replication origin is ready to fire . The activation of S-Cdk in late G1 pulls the trigger and initiates DNA replcation. The initiation of replication also requires the activity of a second protein kinase, which collaborates with S-Cdk to cause the phosphorylation of ORC."

My question: Is there a name for this mystery kinase? I can't seem to find anything on it.

Any help would be greatly appreciated. Thanks guys.
 
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In G1 phase (under low CDK activity), a protein complex called the “pre-replication complex (pre-RC)” is formed on each origin. The pre-RC contains several proteins including the origin recognition complex (ORC), Cdc6p, Cdt1p, and the six minichromosome maintenance proteins (MCM), Mcm2–7p. The ORC was originally identified as a six-protein complex that specifically bound to S. cerevisiae origins of DNA replication (5), and its homologues have been found in various eukaryotic species, including human (3). In this manuscript, “ORC” refers to S. cerevisiae ORC. The ORC is bound to chromatin at the origins of chromosomal DNA replication throughout the cell cycle and is thought to function as a “landing pad” for the assembly of pre-RC. At the G1-S boundary, CDK and another kinase (Cdc7p-Dbf4p) activate the pre-RC to initiate chromosomal DNA replication.
Source: http://www.jbc.org/content/284/6/3396.long
 

What is the Alberts text and why is it important?

The Alberts text, also known as "Molecular Biology of the Cell", is a textbook that covers the fundamental principles of molecular biology and cell biology. It is considered a highly influential and authoritative source in the field of biology, and is used in many university courses around the world.

Who wrote the Alberts text?

The Alberts text was written by a team of authors, including Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, and Peter Walter. These authors are recognized experts in the field of molecular biology and cell biology.

What topics does the Alberts text cover?

The Alberts text covers a wide range of topics, including the structure and function of cells, DNA replication and repair, gene expression and regulation, protein synthesis and processing, cell signaling, and cell division. It also includes discussions on topics such as evolution, cancer, and developmental biology.

Is the Alberts text suitable for all levels of scientists?

The Alberts text is primarily intended for undergraduate and graduate students studying biology or related fields. However, it is also a valuable resource for researchers and professionals in the field of molecular and cell biology.

Are there any updates or new editions of the Alberts text?

Yes, the Alberts text is regularly updated and revised. The most recent edition, the sixth edition, was published in 2014. It includes new chapters on genomics, systems biology, and stem cells, as well as updates on the latest research in the field.

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