- #1
sameeralord
- 662
- 3
My lec notes only specifies animal hippocampus, eg dog has this and unclear about humans. Humans do have this right, and it is a post mortem diagnostic method of rabies in humans right?
Are negri bodies seen in human who have died from rabies?
In summary, the conversation discussed the presence of the animal hippocampus, specifically in dogs, and its unclear existence in humans. It was confirmed that humans do have the hippocampus and it is used as a post-mortem diagnostic method for rabies. It was also mentioned that humans can get negri bodies from rabies infection, which are viral particle inclusions, but they are not very useful for diagnosis in humans. There is an ELISA test for early detection, but it is still not entirely reliable. The recommended course of action is to take the rabies prophylactic vaccine and the inactivated vaccine for longer immunity, especially for those at high risk.
- #2
bobze
Science Advisor
Gold Member
- 648
- 18
Yes, humans get negri bodies from rabies infection. The negri bodies are viral particle inclusions (ribonuclear proteins) from the massive amounts of virus being produced. For reasons unknown to me (not sure if it is known) rabies really "kicks into over drive" in certain neuron types--Like those in the hippocampus.
The only thing it is really good for is post-mortem confirmation--So they aren't all that useful in humans. There is iirc an ELISA that is more useful for early detection in humans, but I think its still a gamble. The rule is, if in doubt take the rabies prophylatic vaccine (preformed Abs to rabies) along with the inactivated vaccine for longer immunity (people who are "high risk" should get the inactivated anyway).
The only thing it is really good for is post-mortem confirmation--So they aren't all that useful in humans. There is iirc an ELISA that is more useful for early detection in humans, but I think its still a gamble. The rule is, if in doubt take the rabies prophylatic vaccine (preformed Abs to rabies) along with the inactivated vaccine for longer immunity (people who are "high risk" should get the inactivated anyway).
- #3
sameeralord
- 662
- 3
Thanks bobze 
1. Are negri bodies always present in humans who have died from rabies?
No, negri bodies are not always present in humans who have died from rabies. While they are a common symptom, they may not be present in all cases.
2. How are negri bodies formed in humans with rabies?
Negri bodies are formed when the rabies virus infects nerve cells in the brain. The virus replicates in the nerve cells, causing the formation of characteristic cytoplasmic inclusions known as negri bodies.
3. Can negri bodies be detected in living humans with rabies?
No, negri bodies can only be detected in post-mortem brain tissue samples. They cannot be detected in living humans with rabies.
4. Do all animals with rabies exhibit negri bodies?
No, not all animals with rabies exhibit negri bodies. While they are commonly seen in certain animal species, they may not be present in all cases.
5. Are negri bodies specific to rabies or can they be seen in other diseases?
Negri bodies are specific to rabies and can only be seen in individuals infected with the rabies virus. They are not seen in other diseases.
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