Lactate doesn't produce acidosis?

[sameeralord]

Hello guys,

I always thought it did but it seems that it is actually a consequence of acidosis. According to this article http://www.unm.edu/~lkravitz/Article...r/lactate.html

However I don't understand this bit in the article

During vigorous exercise, the ATP (high-energy compound from which the cells derive energy) demands of muscle contraction are considerable. Every time an ATP molecule is split for energy it is broken down into an ADP and inorganic phosphate molecule, with the release of one hydrogen ion (another name for a hydrogen ion is a proton).

ATP + H2O --> ADP + P + energy

I don't see a proton been released in this reaction, also what happened to the H20 in this reaction, shouldn't this reaction be written as

ATP + H2O --> ADP0H + PH + energy

Is the proton of PH released?

Thanks

 

[Ahmed Abdullah]

No, the proton of ADP0H is released.

 

[sameeralord]

No, the proton of ADP0H is released.

Thanks for the response I had a bit of a mental blank in this question. The equation like this is right ATP + H2O --> ADP + P + energy

If you look at the molecular formula phosphate gets the OH.

Also found the answer for the next bit

# The inorganic phosphate and the phosphate groups on ATP and ADP are weakly acidic, and have pK values in the physiological range. The activities of the different forms will vary depending on the pH of the reaction medium, and this will alter the value for DGo.

* HATP3- <==> ATP4- + H +; pK1' = 6.95
* HADP2- <==> ADP3- + H +; pK2' = 6.88
* H2PO4- <==> HPO42- + H +; pK3' = 7.20

(The effect of these pK values is that a H+ is released on ATP hydrolysis, with a stoichiometry which approaches 1 above pK3'. This proton release can be used to assay the reactions of ATP hydrolysis or synthesis, or follow the kinetics if a recoding pH meter is available.)

But I still like to hear other's opinion on the article. Thanks!

 

[Ahmed Abdullah]

lone pair electron from H20 attacks the beta (second) phosphate group of ATP and phospho di-ester bond between beta and gama phosphate is broken.

 

[LudusRex]

Hello,

Thank you for bringing this topic to our attention. I can confirm that lactate does indeed contribute to acidosis, but it is not the direct cause. Acidosis is a condition where the body's pH level becomes too acidic, and it can be caused by a variety of factors, including excessive production of lactic acid.

In the article you mentioned, it is explained that during exercise, the breakdown of ATP releases hydrogen ions (protons) as a byproduct. This is because ATP is converted into ADP and inorganic phosphate, as you correctly stated. However, the article is simplifying the process for easier understanding. In reality, the hydrogen ions released from ATP are quickly buffered by other molecules in the body, such as bicarbonate, to maintain a stable pH level.

Additionally, the reaction shown in the article is a general representation of ATP breakdown and does not include all the molecules involved. The release of a proton (H+) is actually a step in a larger series of reactions that ultimately produce lactate. This lactate then contributes to acidosis by interfering with the body's normal acid-base balance.

I hope this helps to clarify any confusion and further your understanding of this topic. It is always important to critically evaluate information and ask questions, so I commend you for doing so. Keep up the curiosity and scientific thinking!

Best regards,