Biophysics and Tissue Engineering

In summary, modern biophysics has various applications in tissue engineering, particularly in the areas of scaffolding design and co-culturing different cell types. The physical properties of the scaffolding, such as rigidity, play a crucial role in determining the differentiation of stem cells. Additionally, research is being conducted on how mechanical forces and physical structures impact cell vitality and intra-cell diffusion of bio-molecular species. This highlights the importance of approaching tissue engineering with sound science and tight control of material properties in order to achieve meaningful technology.
  • #1
Ali Inam
99
0
I have been given an assignment to find out about the applications of modern biophysics in tissue engineering !

I just need a little background on how biophysics and tissue engineering are inter-related (if they are).


I just had an idea that they might be something about some tissue structures and their physical properties etc..

But really need some proper starting, which I am still unable to find.

Regards !
 
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  • #2
There's a lot of material out there in regards to 'scaffolding'- the materials cells grow on. The physical properties of the scaffolding (rigidity, etc) can determine what type of cell a stem cell will differentiate into. Also, 3-d scaffolding for bone grafts.

There's also a lot of work on co-culturing different cell types, towards making organs.
 
  • #3
Yes,

As Andy had mentioned the "scaffoldings" are very important for tissue engineering. The design of the scaffolding must be approached with sound science and tight control of material properties in order to obtain meaningful technology. There is a considerable attention being placed on how mechanical forces and physical structures play a role in signalling and intra-cell diffusion of bio-molecular species. Naturally we can see that extra-cellular matrices (natural or artificial) will contain many physical properties that will affect cell vitality. Let me find you some links.

http://newscenter.lbl.gov/news-releases/2010/03/11/berkeley-scientists-get-physical-with-cancer/

http://www.sciencemag.org/cgi/content/abstract/sci;327/5971/1380?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=%22Restriction+of+Receptor+Movement+Alters+Cellular+Response%22&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
 

1. What is biophysics?

Biophysics is a branch of science that combines the principles of physics and biology to study the physical processes and mechanisms of living organisms. It involves the use of quantitative and analytical techniques to understand biological systems at the molecular, cellular, and organismal levels.

2. What is tissue engineering?

Tissue engineering is a field of research that aims to create functional human tissues and organs in the laboratory using a combination of engineering principles and biological techniques. This involves culturing cells on scaffolds, which act as a support structure for the cells to grow and differentiate into specific tissue types.

3. How are biophysics and tissue engineering related?

Biophysics and tissue engineering are closely related as biophysical principles and techniques are essential for understanding and manipulating the behavior of cells and tissues in tissue engineering. Biophysical methods are used to study the mechanical, electrical, and biochemical properties of cells and tissues, which are crucial for tissue engineering research and applications.

4. What are some applications of biophysics in tissue engineering?

Biophysics plays a critical role in various tissue engineering applications, such as developing artificial organs, regenerating damaged tissues, and creating new biomaterials for medical implants. Biophysical techniques are also used to study the interaction between cells and biomaterials, which is crucial for designing and optimizing tissue engineering scaffolds.

5. What are the challenges in biophysics and tissue engineering research?

One of the main challenges in biophysics and tissue engineering research is the complexity of biological systems. Understanding and engineering living tissues and organs require a multidisciplinary approach, involving expertise in biology, physics, engineering, and materials science. Another challenge is the need for more advanced and precise biophysical techniques to accurately study and manipulate biological processes at the cellular and molecular levels.

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