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Feedback control for a metabolic pathway

by arunma
Tags: control, feedback, metabolic, pathway
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Apr2-06, 01:47 PM
P: 906
I'm having a problem setting up a certain differential equation which I need to solve a problem. Here's the problem: I'm given a feedback control for a certain metabolic pathway. I've attached a picture of the network below.

Now what I can't figure out is how to write the differential equation which governs the amount that accumulates at any particular node. It says that the reactions, except for the first one, obey a first-order rate law, and that all the rate constants are proprtional. But is the time derivative of S1 equal to f(Sn), or is it equal to f(Sn) - kS2? Also, in general, should I find the time derivative of each Sn by subtracting the incoming and outgoing rates?

I'd appreciate any help that anyone can give me. Thanks.
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