image
Physics Forums Logo
image
image
* Register * Upgrade Blogs Library Staff Rules Mark Forums Read
image
image   image
image

image Adrenaline Share It Thread Tools Search this Thread image
Old Aug15-07, 06:46 PM                  #1
Mr_Bojingles

Mr_Bojingles is Offline:
Posts: 79
Adrenaline

Is it possible to synthesize adrenaline in the lab?
  Reply With Quote
Old Aug15-07, 07:39 PM                  #2
gravenewworld

gravenewworld is Offline:
Posts: 1,022
Originally Posted by Mr_Bojingles View Post
Is it possible to synthesize adrenaline in the lab?
Yes it shouldn't be taht hard.
  Reply With Quote
Old Aug15-07, 10:51 PM                  #3
JGM_14

JGM_14 is Offline:
Posts: 151
our body does it all the time
  Reply With Quote
Old Aug16-07, 09:00 AM                  #4
gravenewworld

gravenewworld is Offline:
Posts: 1,022
I did a search for possible starting materials and looked at the cost vs. how many steps for a possible synthesis and you could do it this way:

Buy 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone, 97% (500 g, $283 Alpha Aesar)

Do a substitution of the chlorine with methyl amine (use a large excess of methyl amine).


Reduce the carbonyl stereoselectively using 1H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole, tetrahydro-1-methyl-3,3-diphenyl-, (S)- with Borane Dimethyl sulfide complex in THF.

I've done the reduction before, it works pretty well (>75% yield)

That should give you adrenaline.
  Reply With Quote
Old Aug18-07, 03:08 PM                  #5
quetzalcoatl9

quetzalcoatl9 is Offline:
Posts: 695
Originally Posted by JGM_14 View Post
our body does it all the time
that doesn't means it's easy, in fact it's generally the opposite. enzymes regularly do chemistry that we cant dream of doing in the lab.
  Reply With Quote
Old Sep7-07, 07:50 PM                  #6
JGM_14

JGM_14 is Offline:
Posts: 151
Talking

Originally Posted by quetzalcoatl9 View Post
that doesn't means it's easy, in fact it's generally the opposite. enzymes regularly do chemistry that we cant dream of doing in the lab.
Point taken.
  Reply With Quote
Old Sep11-07, 12:01 PM                  #7
brewnog
 
brewnog's Avatar

brewnog is Offline:
Posts: 2,401
Recognitions:
PF Contributor PF Contributor
Science Advisor Science Advisor
Apparently, it was first synthesised in the lab in 1904 by Freidrich Stolz...
  Reply With Quote
Old Oct4-07, 12:53 PM                  #8
Remnant

Remnant is Offline:
Posts: 19
Hint: Meth is 1 atom away from adrenaline..
  Reply With Quote
image image
Reply
Thread Tools


Similar Threads for: Adrenaline
Thread Thread Starter Forum Replies Last Post
Happy Birthday Adrenaline!!!!!!!!11111111 Evo General Discussion 10 Jul24-07 07:23 AM
Artificial Adrenaline Line Biology 10 Oct9-06 03:57 PM
Belated Happy Birthday Adrenaline!!!!!!!!!!!!! Evo General Discussion 14 Aug1-05 11:49 PM
Adrenaline Information EIRE2003 Biology 1 Dec21-04 06:47 PM

Powered by vBulletin Copyright ©2000 - 2010, Jelsoft Enterprises Ltd. © 2009 Physics Forums
Sciam | physorgPhysorg.com Science News Partner
image
image   image