NITRIC OXIDE CARDIO vascular system

djflush

any ideas of good papers on this molecule in the cardiovascular system vasodilation etc

jim mcnamara

Here is one place to start and follow the links for a lot of related papers.

http://www.ncbi.nlm.nih.gov/pubmed/9576114

Is this your idea of a series of good papers? Or did you want a a review paper?

djflush

well basically im trying to gain a good understanding of the area using papers.Like i know its an endothelium derived vasodilator. Also that NO upregulates the conversion of GMP to cyclic GMP, and cGMP fuels Protein Kinase G, which phosphorylates...something I forget what, which decreases intracellular calcium. Calcium is what ultimately contracts your smooth muscle, so when intracellular calcium is decreased, you have smooth muscle relaxation.But im trying to find out more about its purpose in the cardiovascular system while using papers to help explain it.Also if i can find graphs this would be a bonus as it may make some ponits more clear.Any help would be really appreciated.

jim mcnamara

You need a textbook more than a smattering of papers. I'll look around. Maybe Moonbear or someone else is more current with this area and can suggest something better.