stuff like "reverse-engineering" the brain, creating more environmentally-friendly energy, better medicines, etc etc:
http://www.engineeringchallenges.org/cms/8996/9221.aspx
in wired
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What are they?
* Make solar energy affordable.
* Provide energy from fusion.
* Develop carbon sequestration methods.
* Manage the nitrogen cycle.
* Provide access to clean water.
* Restore and improve urban infrastructure.
* Advance health informatics.
* Engineer better medicines.
* Reverse-engineer the brain.
* Prevent nuclear terror.
* Secure cyberspace.
* Enhance virtual reality.
* Advance personalized learning.
* Engineer the tools for scientific discovery.
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http://blog.wired.com/wiredscience/2...he-14-big.html