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Joe DeRisi: ViroChip, TED Video Jan 2009

by rhody
Tags: derisi, dna, virochip
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rhody
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Feb14-10, 04:37 PM
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Molecular Biologist & Biochemist: Joe DeRisi: who, quoting his TED bio:

"His approach combines scientific rigor with a nerd's boundary-breaking enthusiasm for new techniques."





Video
Highlights:
00:40 Single diagnostic assay to screen for all pathogens simultaneously
01:20 Evolution is a balance, fast change versus ultra conservation
03:00 Grad school, making DNA on chips, thousands
03:50 For the cost of a Camry, (off the shelf parts) you can build a DNA array machine in your garage
04:20 All human respiratory viruses on one chip
06:35 Rhino viruses that have never seen a genetic sequencer
07:50 Testing the detection mechanism, day 2, strong signature
09:30 Made a chip: 22000+ viral sequences in Gen Bank as of June 2004
10:20 Undiagnosed virus used with the new Chip
11:20 Patient on ventilation from ravages of unknown viral agent
11:45 Open lung biopsy performed in trying to isolate the virus
12:30 Ran sample on the Viral Chip saw parainfluenza-4, no data to support how parainfluenza-4 causes lung failure
14:00 Viral signature revealed on samples of men with prostate cancer, and a mutation in antiviral defense enzyme, have a signature for a new retro virus 40% of the time
14:50 Cloned whole virus closely relates to mouse virus, xenotropic virus
15:15 From tumor samples the virus can be located
Summary: Raises more questions than answers, but that's how science works

This presentation may give students studying to be biologists, biochemists something to think about when making career choices...
Our medical community needs more entrepeneurs like DeRisi IMHO

Featured: NY Times

Enjoy: Rhody...
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