Register to reply

Free energy and irreversible processes

by arwelbath
Tags: energy, free, irreversible, processes
Share this thread:
arwelbath
#1
Sep30-04, 08:03 AM
P: 10
Hi,
I'm working on a problem of the thermal stability of a protein. Conventionlly, people compare protein thermal stability in terms of the Gibbs free energy difference between the native and unfolded state. So if it reversibly falls apart, then for N <==> U, DG(N-U) is accessed from the classical equilibrium constant for the process. (DG = -RT ln K)

But, unfortunately my system unfolds irreversibly so that N --> U.

Is the gibbs free energy defined for an irreversible process? If so, how can it be calculated without an equilibrium constant? If it's not defined, is there an equilvalent quantity which can be used?

The best I can do so far is to look at the kinetics, which I've done and got an Arrhenius activation energy. Can I get any more information from this?

Please Help!!
Phys.Org News Partner Physics news on Phys.org
Engineers develop new sensor to detect tiny individual nanoparticles
Tiny particles have big potential in debate over nuclear proliferation
Ray tracing and beyond
cdirk11
#2
Sep30-04, 04:51 PM
P: 2
I'm pretty sure you can find delta G by using the equation
delta G = (delta H) - delta(TS) --> delta G = (Cp * delta T) - (TfSf - TiSi)

Hope this helps


Register to reply

Related Discussions
Thermodynamically irreversible processes Introductory Physics Homework 5
Mollier diagram question on processes?(Reversible or irreversible) Engineering, Comp Sci, & Technology Homework 0
Free energy Biology, Chemistry & Other Homework 3
Free Energy? General Discussion 9
Free Energy! General Discussion 11