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Competitive antagonism in Schild plot

by jayadds
Tags: antagonism, competitive, plot, schild
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jayadds
#1
Jul16-13, 12:05 AM
P: 42
Hi all,

I was just wondering, why is the slope of the Schild plot equal to 1 when competitive antagonism occurs? If possible, can you please explain it by relating to the equation:

log(r-1) = logx - logK

where r = dose ratio, x = antagonist concentratoin and K = dissociation constant

Many thanks,
Jay
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