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Why doesn't decreased insulin secretion during stress cause problems?

by tarekatpf
Tags: decreased, insulin, secretion, stress
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Aug31-13, 10:25 AM
P: 138
During fight-or-flight situations, alpha 2 receptors ( which are inhibitory receptors ) of the pancreatic beta cells are stimulated, and as a result there's decreased insulin production. While it benefits the body by producing increased blood sugar level, I don't understand why Insulin doesn't cause some problems. Such as, since insulin increases glucose intake by the muscle tissues ( skeletal muscles are supposed to be used more in flight-or-fight situations ) and increases glycolysis ( which produces energy ), wouldn't decreased insulin release during flight-or-fight situations cause less glucose intake and less glycolysis ( as a result less energy production ) by the muscle tissues? And wouldn't less energy produced by the muscle tissues cause them work less efficiently?
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Aug31-13, 09:02 PM
PF Gold
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Epinephrine acts by binding to a variety of adrenergic receptors. Epinephrine is a nonselective agonist of all adrenergic receptors, including the major subtypes α1, α2, β1, β2, and β3.[15] Epinephrine's binding to these receptors triggers a number of metabolic changes. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis in muscle.[20]

Reference [20] (a text book):
Sep1-13, 04:34 AM
P: 138
Thank you very much.

Oct31-13, 12:37 AM
P: 21
Why doesn't decreased insulin secretion during stress cause problems?

Overall ongoing research also confirms that muscles can increase their glucose uptake
via other receptors or channels independent of INSULIN also.
Adrenaline pumps them up !

reference Ganong medical physiologe 23 edition.
Oct31-13, 11:43 AM
Evo's Avatar
P: 26,545
Quote Quote by Manish7 View Post
reference Ganong medical physiologe 23 edition.
Please post a link to the specific passage you are referencing in this book. Thank you. The book is copyrighted, so you may only quote the specific passage.

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