Why myeloid-erythroid ration is 4:1 while more RBC's in blood?


by tarekatpf
Tags: blood, myeloiderythroid, ration
tarekatpf
tarekatpf is offline
#1
Sep9-13, 09:10 AM
P: 123
In the bone marrow, the normal ratio of myeloid and erythroid series cells is 4:1. So, for every erythroid cell, there are four myeloid cells, which gives
But in the circulation, there are almost 1000 times more RBC's than total WBC's ( which also includes non-myeloid WBC's, such as lymphocytes. )

Why is it so?
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SW VandeCarr
SW VandeCarr is offline
#2
Sep9-13, 10:21 PM
P: 2,490
Quote Quote by tarekatpf View Post
In the bone marrow, the normal ratio of myeloid and erythroid series cells is 4:1. So, for every erythroid cell, there are four myeloid cells, which gives
But in the circulation, there are almost 1000 times more RBC's than total WBC's ( which also includes non-myeloid WBC's, such as lymphocytes. )

Why is it so?
http://en.wikipedia.org/wiki/Bone_marrow

I'm not sure it is so. Myelopoietic cells constitute 56.6% of parenchymal cells while erythropoietic cells constitute 25.6% of such cells. Erythrocytes circulate for about 120 days while leukocytes circulate for about 3-4 days. This may explain part of the perceived imbalance. No teleologic explanation is required for the rest of the perceived imbalance, but it might be that the bone marrow holds a reserve of myelopoietic cells for emergencies.

EDIT: Allowing for the possibility of an error in my addition, it's still clear the ratio is closer to 2:1.


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