Register to reply

Why is dry tap found during bone marrow aspiration in leukaemia?

by tarekatpf
Tags: aspiration, bone, leukaemia, marrow
Share this thread:
tarekatpf
#1
Sep20-13, 10:03 AM
P: 138
Dry tap means failure to obtain any material at all during bone marrow aspiration.

In leukaemia, aren't you supposed to find at least some material, like abnormally growing cancer cells? Similarly, in multiple myeloma, abnormal plasma cells can be found.

But in my haematology textbook, it's said that dry tap is found in cases of multiple myeloma, leukaemia etc. Why?
Phys.Org News Partner Medical research news on Phys.org
Partially hydrogenated oils in nine percent of packaged foods
Complication rates low with mastectomy, breast reconstruction: study
Obesity fueling rise in diabetes rates, study finds
SW VandeCarr
#2
Sep20-13, 06:52 PM
P: 2,501
Quote Quote by tarekatpf View Post
Dry tap means failure to obtain any material at all during bone marrow aspiration.

In leukaemia, aren't you supposed to find at least some material, like abnormally growing cancer cells? Similarly, in multiple myeloma, abnormal plasma cells can be found.

But in my haematology textbook, it's said that dry tap is found in cases of multiple myeloma, leukaemia etc. Why?
http://www.ncbi.nlm.nih.gov/pubmed/2239919

This particular study (abstract) did not mention multiple myeloma, but any condition that can lead to hypercellularity and/or fibrosis in the bone marrow can create a mechanical barrier to aspiration due to increased tissue density. The listed conditions in this article include chronic myeloid leukemia, myelofibrosis, hairy cell leukemia (a rare type of chronic lymphocytic leukemia) and metastatic carcinoma. All are chronic conditions (except possibly metastatic carcinoma), which over time, change the tissue characteristics of the bone marrow. This study indicates that most dry taps are due to disease, not faulty technique (about 93% in their series).

Another study found Hodgkin's disease was the most common cause of 'dry tap' in their series while multiple myeloma was the least common. This study was able to use small amounts of cell material in the needle. The first study used simultaneous taps and bone marrow biopsies..

http://www.ncbi.nlm.nih.gov/pubmed/382344
tarekatpf
#3
Sep21-13, 08:14 AM
P: 138
Quote Quote by SW VandeCarr View Post
http://www.ncbi.nlm.nih.gov/pubmed/2239919

This particular study (abstract) did not mention multiple myeloma, but any condition that can lead to hypercellularity and/or fibrosis in the bone marrow can create a mechanical barrier to aspiration due to increased tissue density. The listed conditions in this article include chronic myeloid leukemia, myelofibrosis, hairy cell leukemia (a rare type of chronic lymphocytic leukemia) and metastatic carcinoma. All are chronic conditions (except possibly metastatic carcinoma), which over time, change the tissue characteristics of the bone marrow. This study indicates that most dry taps are due to disease, not faulty technique (about 93% in their series).

Another study found Hodgkin's disease was the most common cause of 'dry tap' in their series while multiple myeloma was the least common. This study was able to use small amounts of cell material in the needle. The first study used simultaneous taps and bone marrow biopsies..

http://www.ncbi.nlm.nih.gov/pubmed/382344
Thank you very much.


Register to reply

Related Discussions
Do white blood cells increase or decrease in leukaemia? Medical Sciences 2
Bone marrow test or blood test Biology 0
Syringe Aspiration General Physics 0
Transfusion/marrow transplant for aids treatment Medical Sciences 2
That woman who found tissue in T-rex bone Biology 4