Could We Avoid Fatal Degenerative Brain Disease Through Cloning?

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Discussion Overview

The discussion revolves around the inevitability of fatal degenerative brain diseases and the potential for cloning as a means to extend life and mitigate these conditions. Participants explore the implications of aging, neuron loss, and the nature of various degenerative diseases, including Parkinson's disease and Alzheimer's disease.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • One participant questions whether fatal degenerative brain disease is inevitable and proposes the idea of cloning as a potential solution to extend life.
  • Another participant provides information on the progressive loss of dopaminergic neurons with age, noting that this loss is linked to Parkinson's disease and that symptoms arise after a significant threshold of neuron loss is reached.
  • It is suggested that while many may not live long enough to reach the threshold for degenerative diseases, extending life could reveal more degenerative processes that could lead to suffering or death.
  • A participant clarifies that while Parkinson's disease is not fatal, Alzheimer's disease is considered fatal.
  • Another contribution highlights the severity of degenerative nerve diseases, noting their impact on various bodily functions and the genetic factors involved.

Areas of Agreement / Disagreement

Participants express differing views on the inevitability of degenerative brain diseases and the implications of living longer through cloning. There is no consensus on whether cloning could effectively prevent these diseases or the nature of their fatality.

Contextual Notes

Some assumptions regarding the mechanisms of degenerative diseases and the effects of cloning on longevity remain unaddressed. The discussion reflects a range of perspectives on the genetic and environmental factors influencing these conditions.

dreamingofouterspace
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Is fatal degenerative brain disease inevitable? If we could transplant ourselves into clones every 20 years or something like that, how long would we be able to live before degenerative brain disease, or something like that, killed us?
 
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There is a progressive loss of dopaminergic neurons of the brain as we age, somewhere close to 13% per decade after age 45 (some loss occurs before this time as well, it's just not as rapid). This is the type of neuron which is lost in Parkinson's disease (PD). In order to develop symptoms of PD a certain threshold limit of damage must be attained, believed to be about 70% neuron loss, once this happens clinical symptoms of PD can occur. Certain people in a population may be more prone to developing this, others not, its not a completely understood disease and is generally termed idiopathic PD, because the cause is unknown. There is also an early-onset PD which strikes rather young people, Michael J. Fox for example, and some forms of heritable familial PD. This is the brain region/disease I am most familiar with, so there may be other examples, Alzheimer's and Amyotrophic lateral sclerosis come to mind.

Most people will not live long enough to encounter the above mentioned threshold, but it is always there and if we were somehow able to extend our lives, more and more degenerative processes would be be un-masked and we would eventually die, or suffer, from those.
 
So we would eventually suffer, (If we lived a really long time) but not necessarily die, from degenerative processes?
 
PD is not fatal, Alzheimer's is.
 
The degenerative brain disease is so severe one which affects the whole nervous system.
Degenerative nerve diseases cause worsening of many of your body's activities, including balance, movement, talking, breathing and heart function. Many of these diseases are genetic, which means they run in families or you have a genetic mutation.


http://www.brainhealthandpuzzles.com/brain_disease.html
 

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