Why do the brochioles collapse?

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SUMMARY

Bronchioles collapse primarily due to increased pressure required for exhalation in emphysema patients. The degradation of elastin, caused by the enzyme elastase released by phagocytes, leads to compromised alveolar function. This loss of elasticity prevents the bronchioles from remaining open during exhalation, exacerbating the condition. The discussion highlights the critical relationship between alveolar elasticity and bronchiolar stability.

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Cheman
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I have read the following in a textbook: "In emphysema, phagocytes release the enzyme elastase, which causes the alveoli to lose their elasticity. This interferes with their ability to relax and thus your ability to exhale. This also causes the bronchioles to collapse, which further prevents exhalation, and causes many alveoli to burst."

My question is why do the brochioles collapse?

Thanks in advance. :smile:
 
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Cheman said:
My question is why do the brochioles collapse?

The collapse is said to come about by the increase in pressure that is required to exhale. The excessive pressure is required due to compromised alveolar function, initiated by the degradation of elastin as you mention, and this overcomes the ability of the bronchioles to remain open. Check out http://rtmagazine.com/Articles.ASP?articleid=R0110A04 under "pathophysiology".
 
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