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Neuroscience of memory: book suggestions

by abaaroft
Tags: book, memory, neuroscience, suggestions
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abaaroft
#1
Aug7-14, 08:34 AM
P: 2
I want to delve into the topic of the way the mind works in terms of storing and retrieving memory, and all sources that I can find through Google (wikipedia etc) seem to cover this from a psychological perspective without going into any detail as to how the individual neurons/synapses network in order to store memories.

I cannot find anywhere where short-term/long-term memory is actually explained from a biochemical perspective from the ground up, from the very beginning without assuming anything from any models. Could anyone recommend a good source for this?

Thanks.
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Pythagorean
#2
Aug7-14, 12:03 PM
PF Gold
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Memory isn't well understood at a reducitonist level. We know that a lot of reductionist mechanisms are related to memory (and further, that there are many kinds of memory). Some such mechanisms are:

Long term potentiation (LTP) [1] can increase excitability of a cell and lead to Hebbian learning [2]. With increased activity, microtubule invasion into dendrites [3] leads to increased surface contact between dendritic spine and axon bouton, which leads to more conducting channels of a synapse, increasing the strength of signaling between the neurons. Also interesting in this regard is silent synapses [4].

[1] http://www.ncbi.nlm.nih.gov/books/NBK10878/
[2] http://penta.ufrgs.br/edu/telelab/3/hebbian_.htm
[3] http://www.jneurosci.org/content/28/49/13094.full\
[4] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819160/

Less understood and more controversial are how other molecular mechanisms and cells play into memory. For instance, one paper proposes prion-like proteins play an important role [5]. There's also a lot of researchers looking at the roles of astrocytes [6] which can form a tripartite synapse with two coupled neurons [7].

[5] http://www.cell.com/cell/abstract/S0092-8674(12)00005-0
[6] http://white.stanford.edu/teach/inde...ing_and_Memory
[7] http://blogforalzheimers.com/wp-cont...e-12-31-11.jpg
abaaroft
#3
Aug7-14, 09:13 PM
P: 2
Very helpful and interesting, I'll look into those studies, thanks.

DiracPool
#4
Aug8-14, 12:27 AM
P: 606
Neuroscience of memory: book suggestions

Quote Quote by abaaroft View Post
I want to delve into the topic of the way the mind works in terms of storing and retrieving memory, and all sources that I can find through Google (wikipedia etc) seem to cover this from a psychological perspective without going into any detail as to how the individual neurons/synapses network in order to store memories.

I cannot find anywhere where short-term/long-term memory is actually explained from a biochemical perspective from the ground up, from the very beginning without assuming anything from any models. Could anyone recommend a good source for this?

Thanks.
What's your level of understanding of neurobiology? As far as popular treatments on the subject, there's a few books I can recommend:


Damasio's book...
http://www.amazon.com/The-Feeling-Wh.../dp/0156010755

Freeman's book..
http://www.amazon.com/How-Brains-Mak.../dp/0231120087

And especially, one of my favs, McCrones book
http://www.amazon.com/Going-Inside-S...+consciousness


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