- #1
JS-Student
- 10
- 0
Hi,
I understand that Volume of Distribution (Vd) = elimination constant (k) * Clearance (Cl), but I can't visualize why clearance would be proportional to volume of distribution. Can someone help explain this to me? I feel like it should be a more complicated relationship. Clearance = Mass Drug eliminated/time/Concentration in Plasma. How are these variables changing with different volumes of distribution?
Thanks.
I understand that Volume of Distribution (Vd) = elimination constant (k) * Clearance (Cl), but I can't visualize why clearance would be proportional to volume of distribution. Can someone help explain this to me? I feel like it should be a more complicated relationship. Clearance = Mass Drug eliminated/time/Concentration in Plasma. How are these variables changing with different volumes of distribution?
Thanks.