Can Molecular Assembly Create Living Cells?

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Discussion Overview

The discussion revolves around the concept of creating living cells through molecular assembly, specifically questioning whether a precisely replicated cell at the atomic level would be considered alive. The scope includes theoretical considerations of life, molecular biology, and synthetic biology.

Discussion Character

  • Exploratory
  • Conceptual clarification
  • Debate/contested

Main Points Raised

  • One participant questions if a cell created through molecular assembly, replicating an existing living cell exactly, would be considered alive, highlighting the complexity of defining life.
  • Another participant agrees with the premise but emphasizes the significant uncertainty in achieving such precise replication, referencing synthetic RNA and ongoing projects in synthetic life.
  • A participant expresses a personal perspective, suggesting that many might instinctively affirm the idea of a replicated cell being alive, while also reflecting on their background in biochemistry and the mechanical view of life.
  • This participant further argues that life can be seen as sophisticated mechanics, linking structure with function, and raises the potential for engineering new biological machinery through a deeper understanding of these relationships.

Areas of Agreement / Disagreement

Participants express differing views on whether a synthetically created cell would be considered alive, with some affirming the idea and others highlighting the complexities and uncertainties involved. The discussion remains unresolved regarding the definition of life in this context.

Contextual Notes

Participants acknowledge the challenges in defining life and the limitations of current understanding in molecular assembly and synthetic biology. There are unresolved questions about the implications of replicating life at the atomic level.

sniffer
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i have been reading articles on molecular assemblies and dna design.

my question is: if we take one simple living cell, and using molecular assembly we can create exactly the same copy of that cell (precisely to the atomic level), then will the cell be alive?:bugeye:

thanks.
 
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sniffer said:
if we take one simple living cell, and using molecular assembly we can create exactly the same copy of that cell (precisely to the atomic level), then will the cell be alive?:bugeye:

Yes. But that's a very big 'if' you've stated.

We can make completely synthetic catalytic RNA's. this is a step towards making synthetic life. Craig Venter is (I believe) working on a project to create something like a synthetic bacterium. I am not sure how much of his project involves (artificial) molecular assembly.
 
sniffer said:
i have been reading articles on molecular assemblies and dna design.

my question is: if we take one simple living cell, and using molecular assembly we can create exactly the same copy of that cell (precisely to the atomic level), then will the cell be alive?:bugeye:

thanks.

Well, how many people are like me and reading this before getting to the "thanks" part says to themselves, "why hell yes!". I don't know. Maybe it's just me.:smile:

Perhaps I should qualify: I'm a biologist interested in chemistry but I'm really a Chemist interested in biology. Go figure. Anyway, I suppose you'd expect a "bio-chemist" to take such a "mechanical" vision of life like this.
 
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saltydog said:
Well, how many people are like me and reading this before getting to the "thanks" part says to themselves, "why hell yes!". I don't know. Maybe it's just me.:smile:

Perhaps I should qualify: I'm a biologist interested in chemistry but I'm really a Chemist interested in biology. Go figure. Anyway, I suppose you'd expect a "bio-chemist" to take such a "mechanical" vision of life like this.

i don't think that is at all unreasonable. a chemist realizes that there is no difference between buying Advil or the generically-labelled bottle of "Ibuprofen".

what is life, if not sophisticated mechanics? this, in my opinion, has been on of the greatest contributions of biochemistry - linking structure with function. There has been already been a great deal known about the macroscopic functions of life, but with the advent of radiolabeling, x-ray crystallography, etc. we can determine what is going on at the nano length scale.

examples: the proteosome, ATP synthase, DNA polymerase. Are these not beautiful machines? it is intriguing to consider the possibilities of what additional types of machinery could be engineering if we understood more about the structure-function relationship than we presently do.
 

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