Why do I only have dimples on one side of my face?

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Discussion Overview

The discussion revolves around the phenomenon of having dimples on only one side of the face, exploring genetic explanations and potential biological mechanisms behind this trait. The scope includes genetic dominance, penetrance, and variations in gene expression.

Discussion Character

  • Exploratory
  • Technical explanation
  • Conceptual clarification
  • Debate/contested

Main Points Raised

  • One participant notes that having dimples is a dominant trait but observes that their dimples only appear on one side, questioning the oddity of this occurrence.
  • Another participant suggests that incomplete dominance or variable penetrance might explain the asymmetry in dimple expression, proposing that the musculature responsible for dimples may develop differently on each side.
  • A different viewpoint raises the possibility that there could be distinct genetic traits for having a left dimple, a right dimple, or dimples on both cheeks.
  • A participant references research on the evolution of facial features in cichlid fish, implying that similar principles might apply to human facial traits.
  • One participant challenges the idea of differing gene expression on each side, arguing that typically, gene expression is mirrored across the dorsal-ventral axis, but acknowledges exceptions like heterochromia in eye color, which may relate to mosaicism in X chromosome inactivation.

Areas of Agreement / Disagreement

Participants express multiple competing views regarding the genetic mechanisms behind unilateral dimples, with no consensus reached on the explanations provided.

Contextual Notes

The discussion includes assumptions about genetic dominance and expression that may not be universally applicable, as well as references to specific biological phenomena that require further exploration.

MikeX
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I've notice this for a long time now, but I never remember to inquire about it... until now. I know that having dimples is a dominant trait, but for some reason whenever I smile or laugh, there's only dimples on my left side of my cheek. Isn't this a bit odd?
 
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Hmmm... I know lots of people with one dimple, but haven't given it much thought til now.

I'd think incomplete dominance, or alternatively variable penetrance, would be good possibilities that might explain the situation. For some reason, the musculature that creates a dimple on one side of your face, developed fdifferently on the other side, because the "dominant" gene that gives you a dimple, is not expressed to the same extent ( or not interpreted in the same way) on the other side.

Very few genes show absolute dominance, and you might also consider that some people's dimples are very very deep whereas other people's dimples are more "shallow."
 
perhaps there are different traits for having a left dimple, a right dimple or dimples on both cheeks?
 
Evolution of the cichlid mandible

http://pharyngula.org/index/weblog/comments/evolution_of_the_cichlid_mandible/" is a geat discussion of some research on just this question - evolution and inheritance of facial features - that was done with African fish. Sheds some light. (From Pharyngula, via Panda's Thumb).
 
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Perhaps - but it seems unlikely. Generally speaking, gene expression on one side of the dorsal-ventral axis is mirrored on the other side.

There are cases where the two side are not mirror images. For example, some people have a brown eye and a green eye. In my understanding (which may not be correct) this can be tied into the "mosaicism" that women have one X chromosome inactivated in each cell - and this can vary from one patch of cells to the next.
 

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