What is Transferring: Definition and 119 Discussions

An electron transfer flavoprotein (ETF) or electron transfer flavoprotein complex (CETF) is a flavoprotein located on the matrix face of the inner mitochondrial membrane and functions as a specific electron acceptor for primary dehydrogenases, transferring the electrons to terminal respiratory systems such as electron-transferring-flavoprotein dehydrogenase. They can be functionally classified into constitutive, "housekeeping" ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II).ETFs are heterodimeric proteins composed of an alpha and beta subunit (ETFA and ETFB), and contain an FAD cofactor and AMP. ETF consists of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit. Domains I and III share an almost identical alpha-beta-alpha sandwich fold, while domain II forms an alpha-beta-alpha sandwich similar to that of bacterial flavodoxins. FAD is bound in a cleft between domains II and III, while domain III binds the AMP molecule. Interactions between domains I and III stabilise the protein, forming a shallow bowl where domain II resides.
Mutation in ETFs can lead to deficiency of passing reducing equivalent of FADH2 to electron transport chain, causing Glutaric acidemia type 2

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  1. S

    Other Yahoo! News: Community College units not transferring in California

    There's a news report shown on Yahoo! of community college course credits not accepted for transfer-students to the CSU system schools. (These are schools in California.) https://www.yahoo.com/news/waste-time-community-college-transfers-043010995.html("Other" picked because not sure this...
  2. M

    I Transferring static charge from a Wimshurst machine to a foil pipe

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  3. W

    Transferring Data from Old PC to New PC (Both Win 10)

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  4. archaic

    Schools Transferring to a new university

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  5. K

    Finding power as a function of time in transferring water

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  6. B

    Transferring money from Visa gift card to an account

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  7. Zeppelin34

    Admissions Transferring to UCSC: My Worries and Plans

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  8. Geno

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  9. Mathamans

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  10. MidgetDwarf

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  11. B

    Programs Transferring Math PhD Programs?

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  12. F

    Spring transferring half its energy to each mass?

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  13. J

    Transferring a handheld radio into a antique style radio box

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  14. C

    Schools Where Can I Transfer with a 3.0 GPA for a Physics Degree?

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  15. N

    Schools Which university offers a better physics program: Ohio State or Iowa State?

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  16. obstinatus

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  17. C

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  18. kkefalas

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  19. P

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  20. P

    Programs Transferring to a physics degree [UK]?

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  21. N

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  22. P

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  23. Entanglement

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  24. neosoul

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  25. H

    ABET accreditation, should it be a significant factor?

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  26. C

    Schools Transferring to University from CC: Preparation advice

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  27. J

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  28. Davephaelon

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  29. ellipsis

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  30. J

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  31. T

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  32. B

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  33. R

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  34. J

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  35. A

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  36. T

    Schools Is this a bad idea? Transferring to a not so good college oos

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  38. W

    Programs Transferring Question Regarding Major

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  40. Ascendant78

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  41. P

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  42. M

    Programs Transferring to UT Austin as a physics major.

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  43. A

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  44. T

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  45. A

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  46. S

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  47. Y

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  48. O

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  49. P

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  50. X

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