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Biology and Chemistry Homework Help
Aldol Condensation: Why is OH a Good LG?
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[QUOTE="brake4country, post: 4950534, member: 513310"] [h2]Homework Statement [/h2] In a typical aldol condensation (say 2 aldehydes reacted with NaOH, water, and under heated conditions) why is hydroxide considered a good leaving group in the final step? [h2]Homework Equations[/h2] NA [h2]The Attempt at a Solution[/h2] I drew out a mechanism with an aldehyde and a ketone, creating the aldol product. From here, heat is added and hydroxide is protonated in solution to leave behind a carbanion on the alpha carbon. Once the double bond is created by the electrons OH is push off. How is OH a good leaving group in this case? [ATTACH=full]76731[/ATTACH] [/QUOTE]
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Aldol Condensation: Why is OH a Good LG?
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