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nautica
I am doing some research on ALS. Do any of you have any links on peer reviewed journals or articles.
Thanks
nautica
Thanks
nautica
Clinical trials in amyotrophic lateral sclerosis (ALS) have been conducted for over half a century now and have incorporated a wide variety of drugs. Most of these trials have had negative results and a cure remains elusive. The explosion in our understanding of molecular biology and parallel developments in clinical epidemiology have opened up a vast number of novel therapeutic strategies. However, advances in statistical analysis, computing, and global communications have also put greater pressure on scientific investigators to improve the design and implementation of clinical trials so that they permit rigorous testing of hypotheses within a solid ethical framework. This article documents the first published trial for all drugs tried clinically in the treatment of ALS, focusing in more detail on the large, multicenter trials of recent years, namely those involving riluzole, ciliary neurotrophic factor, insulin-like growth factor-I, brain-derived neurotrophic factor, and SR57746A. The problems in the design of trials in ALS are discussed, including the selection of end points and surrogate markers of disease progression, and the major parameters in ALS assessment are reviewed...
You must be familiar with PubMed right? (part of the National Library of Medicine) www.ncbi.nlm.nih.gov/PubMed/Originally posted by nautica
I am doing some research on ALS. Do any of you have any links on peer reviewed journals or articles.
Thanks
nautica
Peer-reviewed ALS research refers to studies and experiments related to amyotrophic lateral sclerosis (ALS) that have been evaluated and critiqued by experts in the field before being published in a scientific journal. This process ensures that the research is of high quality and meets certain standards.
Peer-reviewed ALS research is valuable because it has been rigorously evaluated by experts in the field, ensuring that the findings and conclusions are reliable and accurate. It also allows for other researchers to build upon the existing knowledge and advance the understanding of ALS.
Peer-reviewed ALS research can be accessed through various sources such as online databases, scientific journals, and academic institutions. Some sources may require a subscription or payment, while others may offer open access to their publications.
Peer-review plays a critical role in the scientific process as it helps to ensure the quality and validity of research. It allows for experts in the field to provide valuable feedback and critique, leading to improvements in the study design, methods, and conclusions.
While peer-reviewed ALS research is generally considered to be of high quality, it is not without its limitations. Some potential limitations include the time and resources required for the peer-review process, potential biases or conflicts of interest among reviewers, and the possibility of overlooked errors or flaws in the research.