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Alternative Splicing Goes Mainstream

  1. Dec 13, 2003 #1

    iansmith

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    http://www.the-scientist.com/yr2003/dec/research2_031215.html
     
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  3. Dec 13, 2003 #2

    selfAdjoint

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    Wow!

    Do I understand correctly that these new functions come into play upstream of messenger RNA? So the new chain would be DNA+Introns => lots of control functions => much tailored mRNA => any of a number of different proteins from the same DNA?
     
  4. Dec 13, 2003 #3

    iansmith

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    It is not exactly like you described. Its splicing site which are specific sequence can be target by the splicesome in a given cellular state. The mRNA is intron and exon. The splicing removes the introns and keeps the exons. The difference is that some exons migth be reject for a certain function but kept for another function. As you said you get many tailored made processed mRNA which in term increase the potential number of protein.
     
  5. Dec 14, 2003 #4

    Monique

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    Upstream of mRNA is a region called the 3'UTR (untranslated region) which plays a role in regulating the translation of the sequence.
     
  6. Dec 14, 2003 #5

    selfAdjoint

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    Is there any account of this that gives some detail but is accessible to a general reader?
     
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