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Bio Question

  1. Aug 26, 2006 #1
    Consider a cell in which you have driven the expression of a constitutively active GTPase Activating Protein (GAP) for CDC42, an important Rho-family GTPase. In these cells, CDC42's activity would most likely be:

    A.Downregulated because activating the GTPase function of CDC42 causes it to be associated with GDP, in which state CDC42 is inactive.
    B.Downregulated because the association of CDC42 with a constitutively active GAP will cause CDC42 to be degraded.
    C.Upregulated because a GAP activates the GTPase it works with.
    D.Unaffected because the association of CDC42 with a constitutively active GAP will cause CDC42 to be degraded.
    E. Upregulated because constitutive activation of any protein will induce a heat-shock response by the cell inducing it to transcribe many genes as quickly as it can.


    I am going towards C, i know it will not be downregulated since there is GTP Avaliable. E just makes no sense so i can get rid of it. So i am left with C and D but im leing towards C
     
  2. jcsd
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