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Blood groups

  1. Jun 2, 2005 #1
    If we give someone with blood group A a transfusion using an O doner we say they are safe, since the O blood cells will not possess antigens to stimulate an immune response in the recipient.

    But surely the O doner blood with contain anti-A antibodies and memory cells that will be stimulated by the A blood cells and should surely lead to agglutination and an immune response - but this doesn't happen. Why?

    Thanks in advance. :smile:
  2. jcsd
  3. Jun 2, 2005 #2
    It is better to give a matching blood type, but in an emergency when the bloodtype is not known group O blood can be given, this may indeed destroy some of the recipients red blood cells. However nowadays a preparation of only red blood cells is given.
  4. Jun 2, 2005 #3
    also, you would expect that the level of anti-A antibodies would be extremely low, probably even none for most O-type people.

    An exception would possibly be a mother of O-type blood that gave birth to an A-type child, or vice versa.
  5. Jun 2, 2005 #4


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    Gerben is true, it is also important to understand that it's a matter of dose:

    From O to A means that there are few anti-A antibodies to a lot of A type blood, only little agglutination will take place.

    Some A blood to an O individual, means that there is a lot of anti-A to a little A type blood. It is now that a severe reaction will take place.
  6. Jun 2, 2005 #5


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    Only the rhesus factor is of concern during the second pregnancy of a Rh- mother.
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