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Boost Response by Delaying Second Dose -- Pfizer vaccine in elderly
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[QUOTE="Ygggdrasil, post: 6494373, member: 124113"] The Pfizer vaccine has already been observed to be very effective in older individuals (the[URL='https://www.nejm.org/doi/full/10.1056/nejmoa2034577'] original Phase III trial [/URL]observed a 100% vaccine efficiency for those >75 (though this was based on a fairly low # of people) and [URL='https://www.nejm.org/doi/10.1056/NEJMoa2101765']real world data from Israel[/URL] indicated a 95% protection for those > age 70. So, delaying the second dose probably would not increase protection very much (hard to do much better than 95% protection) and could actually lead to more disease if the protection before the second dose in weeks 3-11 is not effective as the protection from getting a second dose at week 3. However, this data could be useful in designing vaccines going forward. For example, future vaccines might be able to use a lower dose of vaccine (which would hopefully have lower side effects) with greater spacing to achieve similar levels of protection. [/QUOTE]
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Boost Response by Delaying Second Dose -- Pfizer vaccine in elderly
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