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Can we mimic Turreptosis cellular reversal in humans?
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[QUOTE="Ygggdrasil, post: 6039003, member: 124113"] Here's a link to the paper relating heterochromatin organization to aging: [URL]http://science.sciencemag.org/content/348/6239/1160[/URL] There are very many lab looking into the "epigenetics" of aging (i.e. how DNA and histone modifications as well as chromatin state are involved in the aging process), though this is very much still an active area of research with not too many very solid results (and certainly none that I know of that are clinically actionable). Here's an example of a recent paper on the topic: [URL]https://www.cell.com/cell/abstract/S0092-8674(18)30451-3[/URL] Changes to chromatin state are likely one of very many factors contributing to aging. Aging is very likely a multi-factorial process where there are several essential biological processes involved and failure of anyone of these systems contributes to aging. Thus, solving just one problem will likely not be sufficient to "solve" aging. The research on chromatin and heterochromatin is likely adding to the list of factors contributing to aging, but it is unlikely that the chromatin story will explain all of aging. For a nice review of the biological mechanisms behind aging see the following review published in the journal [I]Cell[/I] (abstract copied below): [URL]https://www.cell.com/abstract/S0092-8674(13)00645-4[/URL] With regard to regeneration in other species, much work has been done to study regeneration in planaria (flatworms), which are more evolutionary related to humans than jellyfish. We have a decent idea of how planaria are able to regenerate (see [URL]https://www.nature.com/scitable/blog/accumulating-glitches/unravelling_regeneration_in_planaria[/URL]), though it's not clear how applicable such knowledge is to humans as these organisms have very different biology than us. Other research is examining other interesting animals to gain clues into aging processes, such as the naked mole rat which does not seem to get cancer. Regarding the different lifespans of various species across the tree of life, see this previous PF thread for some interesting links: [URL]https://www.physicsforums.com/threads/reason-for-different-animals-longevity.900313/[/URL] [/QUOTE]
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