Do the centrosomes start moving toward opposite poles of the cell in prophase or prometaphase in mitosis? Can anyone tell me if my explanation of mitosis is accurate. Interphase - DNA, centrosomes and organelles are replicated. Prophase - Chromosomes condense and nuclear envelope begins to dissolve. Spindle apparatus begins to form on centrosomes. Prometaphase - Nuclear envelope disappears. Centrosomes begin to migrate toward opposite poles of the cell. Spindle fibers attach to chromatids at their kinetochores. Metaphase - Centrosomes have moved to opposite poles of cell. Chromatids align at metaphase plate. Anaphase - Spindle fibers begin to shrink and sister chromatids are pulled apart from one another. Telophase - Nuclear envelopes begin to form around the new two sets of chromosomes. Spindle apparatus begins to break down. Cytokinesis - Cytoplasm is divided into two. Contractile ring of actin forms cleavage furrow and cell begins to divide into 2 daughter cells.